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CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
(Soc Brasileira Quimica, 2022-02-21)
CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, ...
Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells
(Nature Publishing Group, 2016-03-02)
The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of ...
Structure-based drug design to overcome drug resistance: challenges and opportunities
(Bentham ScienceBussum, 2014-02)
Drug resistance is a common concern for the development of novel antiviral, antimicrobial and anticancer therapies. To overcome this problem, several strategies have been developed, many of which involving the theme of ...
Classification of current anticancer immunotherapies
(Impact Journals, 2014-12-18)
During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and ...
El PaclitaxelThe Paclitaxel
(Pontificia Universidad Católica del PerúPE, 2017)
Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows
(Humana Press, 2017)
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, ...