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Computational studies of the reversible domain swapping of p13suc1
(Biophysical Society, 2005-10-01)
A minimalist representation of protein structures using a Go- like potential for interactions is implemented to investigate the mechanisms of the domain swapping of p13suc1, a protein that exists in two native conformations: ...
Computational studies of the reversible domain swapping of p13suc1
(Biophysical Society, 2005-10-01)
A minimalist representation of protein structures using a Go- like potential for interactions is implemented to investigate the mechanisms of the domain swapping of p13suc1, a protein that exists in two native conformations: ...
Complex Energy Landscape of a Giant Repeat Protein
(Cell Press, 2013-11)
Here, we reveal a remarkable complexity in the unfolding of giant HEAT-repeat protein PR65/A, a molecular adaptor for the heterotrimeric PP2A phosphatases. The repeat array ruptures at multiple sites, leading to intermediate ...
The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin
(Elsevier, 2013-07)
The N-terminal stretch of human frataxin (hFXN) intermediate (residues 42?80) is not conserved throughout evolution and, under defined experimental conditions, behaves as a random-coil. Overexpression of hFXN56?210 in E. ...
Deuteron effects in nucleon-nucleus scattering at intermediate energies
(1994-11)
We investigate the role of the full dynamical dependence of the free off-shell nucleon-nucleon t
matrix on the optical potential for proton-nucleus elastic scattering in the 100—400 MeV incident
energy range within a ...
The Essential, Ubiquitous Single-Stranded DNA-Binding Proteins
(2021-01-01)
Maintenance of genomes is fundamental for all living organisms. The diverse processes related to genome maintenance entail the management of various intermediate structures, which may be deleterious if unresolved. The most ...
TorsinA folding and N-linked glycosylation are sensitive to redox homeostasis
(Elsevier Science, 2021-08)
The Endoplasmic Reticulum (ER) is responsible for the folding and post-translational modification of secretory proteins, as well as for triaging misfolded proteins. During folding, there is a complex yet only partially ...