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Physiology and Therapeutic Potential of the Thymic Peptide Thymulin
(Bentham Science Publishers, 2014-07)
Thymulin is a thymic hormone exclusively produced by the epithelial cells of the thymus. After its discovery and initial characterization in the ‘70s, it was demonstrated that the production and secretion of thymulin are ...
Equivalent Neurogenic Potential of Wild-Type and GFP-Labeled Fetal-Derived Neural Progenitor Cells Before and After Transplantation Into the Rodent Hippocampus
(LIPPINCOTT WILLIAMS & WILKINS, 2011)
Introduction. The hippocampal formation is a specific structure in the brain where neurogenesis occurs throughout adulthood and in which the neuronal cell loss causes various demential states. The main goal of this study ...
Effects of bone marrow-derived mononuclear cells on airway and lung parenchyma remodeling in a murine model of chronic allergic inflammation
(ELSEVIER SCIENCE BV, 2011)
We hypothesized that bone marrow-derived mononuclear cells (BMDMC) would attenuate the remodeling process in a chronic allergic inflammation model. C57BL/6 mice were assigned to two groups. In OVA, mice were sensitized and ...
CHARACTERIZATION OF Kiss1 NEURONS USING TRANSGENIC MOUSE MODELS
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism. Within the hypothalamus, Kiss1 mRNA is expressed ...
Anesthetic Activation of Central Respiratory Chemoreceptor Neurons Involves Inhibition of a THIK-1-Like Background K(+) Current
(SOC NEUROSCIENCE, 2010)
At surgical depths of anesthesia, inhalational anesthetics cause a loss of motor response to painful stimuli (i.e., immobilization) that is characterized by profound inhibition of spinal motor circuits. Yet, although clearly ...
Myostatin gene knockdown through lentiviral-mediated delivery of shRNA for in vitro production of transgenic bovine embryos
(CAMBRIDGE UNIV PRESS, 2010)
Myostatin is described as a negative regulator of the skeletal muscle growth. Genetic engineering, in order to produce animals with double the muscle mass and that can transmit the characteristic to future progeny, may be ...
Sugarcane Growth Promotion by the Endophytic Bacterium Pantoea agglomerans 33.1
(AMER SOC MICROBIOLOGYWASHINGTON, 2012)
The promotion of sugarcane growth by the endophytic Pantoea agglomerans strain 33.1 was studied under gnotobiotic and greenhouse conditions. The green fluorescent protein (GFP)-tagged strain P. agglomerans 33.1: pNKGFP was ...
Vitrification of primordial germ cells using whole embryos for gene-banking in loach, Misgurnus anguillicaudatus
(WILEY-BLACKWELLHOBOKEN, 2012)
In gene-banking, primordial germ cells (PGCs), which are embryonic precursor cells of germ cells, are useful for cryopreservation because PGCs have a potential to differentiate into both eggs and sperm via germ-line chimera. ...
Leptin signaling in Kiss1 neurons arises after pubertal development
(Public Library of ScienceSan Francisco, 2013-03-07)
The adipocyte-derived hormone leptin is required for normal pubertal maturation in mice and humans and, therefore, leptin has been recognized as a crucial metabolic cue linking energy stores and the onset of puberty. Several ...
Human multipotent adipose-derived stem cells restore dystrophin expression of Duchenne skeletal-muscle cells in vitro
(PORTLAND PRESS LTD, 2008)
Background information. DMD (Duchenne muscular dystrophy) is a devastating X-linked disorder characterized by progressive muscle degeneration and weakness. The use of cell therapy for the repair of defective muscle is being ...