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Molecular mechanisms of hypertensive nephropathy: Renoprotective effect of losartan through hsp70
(Multidisciplinary Digital Publishing Institute, 2021-11)
Hypertensive nephrosclerosis is the second most common cause of end-stage renal disease after diabetes. For years, hypertensive kidney disease has been focused on the afferent arterioles and glomeruli damage and the ...
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway
(e-Century Publishing, 2017)
Abstract: TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitial damage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy ...
Antifibrotic effects of pioglitazone at low doses on the diabetic rat kidney are associated with the improvement of markers of cell turnover, tubular and endothelial integrity, and angiogenesis
(Karger, 2011-01)
BACKGROUND/AIMS: Pioglitazone and other thiazolidinediones are renoprotective in diabetic nephropathy at doses that normalize glycemia, presumably as a consequence of glycemic control. However, low doses of pioglitazone ...
The role of tubulointerstitial inflammation in the progression of chronic renal failure
(2015)
We determined the serum IgE levels and T-helper (Th)17-related cytokines during distinct hepatitis A virus (HAV)-induced clinical courses in children. A significantly higher concentration of macrophage inflammatory protein ...
Predictive Usefulness of Urinary Biomarkers for the Identification of Cyclosporine A-Induced Nephrotoxicity in a Rat Model
(Public Library Science, 2015)
Renal angiotensin II up-regulation and myofibroblast activation in human membranous nephropathy
(2003-10)
Background. The molecular mechanisms of renal injury and fibrosis in proteinuric nephropathies are not completely elucidated but the renin-angiotensin system (RAS) is involved. Idiopathic membranous nephropathy (MN), a ...
Gestational low-protein intake enhances whole-kidney MIR-192 and MIR-200 family expression and epithelial-to-mesenchymal transition in rat adult male offspring
(2018-05-01)
Studies have shown that adult offspring of mothers fed a protein-restricted diet during pregnancy present a pronounced reduction of nephron number associated with decreased fractional urinary sodium excretion and arterial ...
MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
(2012)
complication is diabetic nephropathy (DN), a clinical syndrome associated with kidney damage and an increased risk of cardiovascular disease. Irrespective of the type of diabetes, DN follows a well-known temporal course. ...