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Leptodactylus latrans amphibian skin secretions as a novel source for the isolation of antibacterial peptides
(Molecular Diversity Preservation International, 2018-11)
Amphibians´ skin produces a diverse array of antimicrobial peptides that play a crucial role as the first line of defense against microbial invasion. Despite the immense richness of wild amphibians in Argentina, current ...
Physical reasons for the unusual α-helix stabilization afforded by charged or neutral polar residues in alanine-rich peptides
(National Academy of Sciences, 2000-11)
We have carried out conformational energy calculations on alanine-based copolymers with the sequence Ac-AAAAAXAAAA-NH2 in water, where X stands for lysine or glutamine, to identify the underlying source of stability of ...
A quasi-spontaneous amyloid route in a DNA binding gene regulatory domain: The papillomavirus HPV16 E2 protein
(Wiley, 2007-12)
The DNA binding domain of papillomavirus E2 proteins is at the center of the regulation of gene transcription and replication of the virus. Its unique fold consists of a beta-barrel domain that combines an eight-stranded ...
Truncation of a β-barrel scaffold dissociates intrinsic stability from its propensity to aggregation
(Cell Press, 2012-11)
Δ98Δ is a functional all-β sheet variant of intestinal fatty acid binding protein (IFABP) that was generated by controlled proteolysis. This framework is useful to study the molecular determinants related to aggregation ...
Síntese, análise conformacional, avaliação do potencial de liberação em implante de PLGA e ensaios de atividade antiangiogênica e de citotoxicidade do peptídeo PSAIWF-NH2
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE QUÍMICAPrograma de Pós-Graduação em QuímicaUFMG, 2021-09-22)
This work reports the synthesis of the peptide PSAIWF-NH2 using the 9fluorenylmethoxycarbonyl (Fmoc) solid phase approach. In a previous investigation performed by our research group, this peptide showed considerable ...
Anoplin, a novel antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis
(Elsevier B.V., 2001-11-26)
A novel antimicrobial peptide, anoplin, was purified from the venom of the solitary wasp Anoplius samariensis. The sequence was mostly analyzed by mass spectrometry, which was corroborated by solid-phase synthesis. Anoplin, ...
Model peptides mimic the structure and function of the N-terminus of the pore-forming toxin sticholysin II
(Wiley-Blackwell, 2006-01-01)
To investigate the role of the N-terminal region in the lytic mechanism of the pore-forming toxin sticholysin II (St II), we studied the conformational and functional properties of peptides encompassing the first 30 residues ...
Model peptides mimic the structure and function of the N-terminus of the pore-forming toxin sticholysin II
(Wiley-Blackwell, 2006-01-01)
To investigate the role of the N-terminal region in the lytic mechanism of the pore-forming toxin sticholysin II (St II), we studied the conformational and functional properties of peptides encompassing the first 30 residues ...
Anoplin, a novel antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis
(Elsevier B.V., 2001-11-26)
A novel antimicrobial peptide, anoplin, was purified from the venom of the solitary wasp Anoplius samariensis. The sequence was mostly analyzed by mass spectrometry, which was corroborated by solid-phase synthesis. Anoplin, ...
Adepamycin: design, synthesis and biological properties of a new peptide with antimicrobial properties
(Elsevier B.V., 2020-09-30)
Antimicrobial peptides (AMP) are molecules with a broad spectrum of activities that have been identified in most living organisms. In addition, synthetic AMPs designed from natural polypeptides have been largely investigated. ...