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Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
(Associação Brasileira de Divulgação Científica, 2001-02-01)
Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently ...
Na+ coordination at the Na2 site of the Na+/I- symporter
(National Academy of Sciences, 2016-09)
The sodium/iodide symporter (NIS) mediates active I(-) transport in the thyroid-the first step in thyroid hormone biosynthesis-with a 2 Na(+): 1 I(-) stoichiometry. The two Na(+) binding sites (Na1 and Na2) and the I(-) ...
Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms
(ELSEVIER IRELAND LTDCLARE, 2012)
Iodine is a critical element involved in thyroid hormone synthesis. Its efflux into the follicular lumen is thought to occur, in part, through pendrin at the apical membrane of thyrocytes. This study attempted to investigate ...
Differential gene expression analysis of iodide-treated rat thyroid follicular cell line PCCl3
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
The inhibitory effect of supraphysiological iodide concentrations on thyroid hormone synthesis (Wolff - Chaikoff effect) and on thyrocyte proliferation is largely known as iodine autoregulation. However, the molecular ...
Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na + -driven transporters
(Rockefeller University Press, 2015-05)
Prokaryotic and eukaryotic Na(+)-driven transporters couple the movement of one or more Na(+) ions down their electrochemical gradient to the active transport of a variety of solutes. When more than one Na(+) is involved, ...