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Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer
(Impact Journals, 2017)
Gallbladder cancer (GBC) is a lethal cancer with poor prognosis associated with high invasiveness and poor response to chemotherapy and radiotherapy. New therapeutic approaches are urgently needed in order to improve ...
Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation
(Cell Press, 2018-03)
The inherent tendency of proteins to convert from their native states into amyloid aggregates is associated with a range of human disorders, including Alzheimer's and Parkinson's diseases. In that sense, the use of small ...
Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
(SOC BIOLGIA CHILE, 2008)
We have previously characterized a number of small molecule organic compounds that prevent the
aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now
evaluated the effects ...
Cathepsin L inhibitors with activity against the liver fluke identified from a focus library of quinoxaline 1,4-di-N-Oxide derivatives
(MDPI, 2019)
Infections caused by Fasciola species are widely distributed in cattle and sheep causing significant economic losses, and are emerging as human zoonosis with increasing reports of human cases, especially in children in ...
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators
(The American Society for Biochemistry and Molecular Biology, Inc., 2013)
XIAP as a Target of New Small Organic Natural Molecules Inducing Human Cancer Cell Death
(2019)
X-linked inhibitor of apoptosis protein (XIAP) is an emerging crucial therapeutic target in
cancer. We report on the discovery and characterisation of small organic molecules from Piper genus
plants exhibiting XIAP ...
The Development of Coronavirus 3C-Like Protease (3CLpro) Inhibitors from 2010 to 2020
3CLpro is a key enzyme for the maturation of all coronaviruses and has hence
been recognized as a potent drug target for the treatment of coronavirus infection. The
present review focuses on the status of various efficacious ...
Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells
(Dove Press, 2014-07)
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases ...
Purification and characterization of a novel thermostable papain inhibitor from Moringa oleifera with antimicrobial and anticoagulant properties
(Multidisciplinary Digital Publishing Institute, 2021-04)
Plant cystatins (or phytocystatins) comprise a large superfamily of natural bioactive small proteins that typically act as protein inhibitors of papain-like cysteine proteases. In this report, we present the purification ...
Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients
(Elsevier Ireland Ltd, 2017)
JAK proteins have been linked with survival and proliferation of multiple myeloma (MM) cells