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Fluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 beta-cells
(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg GMBH, 2015)
Introduction: Pancreatic -cells synthetize and store Serotonin (5-Hydroxytriptamine, 5HT) which is co-released with insulin. It has been proposed that extracellular 5HT binds to specific cell surface receptors and modulate ...
The nervous and prenervous roles of serotonin in Echinococcus spp.
(Elsevier, 2013-03)
Serotonin (5-hydroxytryptamine, 5-HT) is an important neuroactive and morphogenetic molecule in several metazoan phyla, including flatworms. Serotoninergic nervous system studies are incomplete and 5-HT function/s are ...
Early life stress and macaque annygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene
(Frontiers Research Foundation, 2014-10-06)
Background: Children exposed to early life stress (ELS) exhibit enlarged amygdala volume in comparison to controls. the primary goal of this study was to examine amygdala volumes in bonnet macaques subjected to maternal ...
Is the antidepressant activity of selective serotonin reuptake inhibitors mediated by nicotinic acetylcholine receptors?
(Molecular Diversity Preservation International, 2021-04)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates ...
Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats
(Academic Press Inc Elsevier Science, 2018-11)
Aerobic exercise (AE) benefits brain health and behavior. Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are known to mediate and shape cognitive processes. Both systems share some actions: BDNF is involved ...
The effect of 4-methyl-thioamphetamine on olfactory responses in Drosophila is explained by an increased serotonin release in the fly brain
(2015)
4-MTA (4-Methylthioamphetamine) is a “designer drug” which induces prolonged stimulation and euphoria, and has been
associated with neurotoxicity and even death. It was designed to specifically block the serotonergic plasma ...
Increased serotonin release in the brain underlies the effect of 4-MTA on olfactory responses in Drosophila.
(2015)
4-MTA (4-Methylthioamphetamine) is a “designer drug” which
induces prolonged stimulation and euphoria, and has been associated
with neurotoxicity and even death. It was designed to specifically
block the serotonergic plasma ...
Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA (“Ecstasy”) in Rats and Preserves Affinity for the Serotonin Transporter (SERT)
(Frontiers Media S.A., 2019)
The entactogen MDMA (3,4-methylenedioxy-methamphetamine, “Ecstasy”) exerts its psychotropic effects acting primarily as a substrate of the serotonin transporter (SERT) to induce a non-exocytotic release of serotonin. ...
SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior
(Nature Publishing Group, 2019-05)
Antidepressants that block the serotonin transporter, (Slc6a4/SERT), selective serotonin reuptake inhibitors (SSRIs) improve mood in adults but have paradoxical long-term effects when administered during perinatal periods, ...