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Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study
(2019)
Recent evidence has raised in discussion the possibility that cannabidiol can act as a negative allosteric modulator of the cannabinoid type 1 receptor. Here we have used computational methods to study the modulation exerted ...
Modulation of androgen receptor protein by culture conditions of human skin fibroblasts
(2002)
Cultures of skin fibroblasts show variation of androgen binding with culture conditions; binding variations are usually avoided by using confluent cultures. In this work, we analysed the effect of cell density and mitogenic ...
Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors
(Society for Neuroscience, 2009)
Characterization of the dizocilpine binding site on the nicotinic acetylcholine receptor
(American Society for Pharmacology and Experimental Therapeutics, 2001-05)
Although the dissociative anesthetic dizocilpine [(+)-MK-801] inhibits nicotinic acetylcholine receptor (AChR) function in a noncompetitive manner, the location of the dizocilpine binding site(s) has yet to be clearly ...
Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor
Study of the interactions established between the viral glycoproteins and their host
receptors is of critical importance for a better understanding of virus entry into cells. The
novel coronavirus SARS-CoV-2 entry into ...
GABA released from cultured cortical neurons influences the modulation of t-[35S]butylbicyclophosphorothionate binding at the GABAA receptor: Effects of thymol
(Elsevier Science, 2008-12)
Thymol is a monoterpene that specifically interacts with synaptic neural functions in neuronal GABA-operated Cl- channels. Here we explore the effects of thymol, and propofol as positive control, on t-[35S]butylbicycloph ...
Only subtle protein conformational adaptations are required for ligand binding to thyroid hormone receptors: Simulations using a novel multipoint steered molecular dynamics approach
(AMER CHEMICAL SOC, 2008)
Thyroid hormone receptors (TR) are hormone-dependent transcription regulators that play a major role in human health, development, and metabolic functions. The thyroid hormone resistance syndrome, diabetes, obesity, and ...
Ethanol's Action Mechanisms in the Brain: From Lipid General Alterations to Specific Protein Receptor Binding
(2017-02-23)
Ethanol is the most popular addictive substance used in the word. Its small and relatively simple structure facilitates its access to brain tissues and binding to many sites. This relatively unspecific action can partially ...