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Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer
(Nature Publishing Group, 2014-08-01)
The microRNA (miR)-200s and their negative regulator ZEB1 have been extensively studied in the context of the epithelial mesenchymal transition. Loss of miR-200s has been shown to enhance cancer aggressiveness and metastasis, ...
Radiosensitivity of radiotherapy patients: The effect of individual DNA repair capacity
(Elsevier Science, 2021-07)
Individual radiosensitivity is a critical problem in radiotherapy because of the treatment restrictions it imposes. We have tested whether induction/repair of genomic lesions correlates with the acute cutaneous effects of ...
Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients
(Elsevier Science, 2018-12)
Although oncological therapies have improved in the last decades, breast cancer (BC) remains a serious health problem worldwide. Radiotherapy (RT) is one of the most frequently used treatments for cancer aimed at eliminating ...
Avaliação do efeito radiomodificador do resveratrol sobre células de câncer de mama (MCF-7) irradiadas
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2016-11-28)
Malignant neoplasias constitute a public health issue, with around 600 thousand new cases of cancer projected to be diagnosed in Brazil between 2016 and 2017. In this context, breast cancer is the most common type in women, ...
Bacillus Calmette-Guerin improves local and systemic response to radiotherapy in invasive bladder cancer
(Academic Press Inc Elsevier Science, 2017-04)
BackgroundA key factor contributing to radio-resistance in conservative invasive bladder cancer (BCa) treatment is tumor hypoxia and a strategy to overcome it is to trigger the production of nitric oxide (NO). On the other ...
Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
(Elsevier, 2018)
Abstract: Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to ...