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Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control
(2022-02-28)
Although there are several pathways to ensure that proteins are folded properly in the cell, little is known about the molecular mechanisms regulating histone folding and proteostasis. In this work, we identified that ...
Studying the role of BiP as a chaperone through single molecule force spectroscopy
(Universidad de Chile, 2016)
El control de calidad y la proteostasis son procesos cruciales en la célula para mantener la
homeostasis, y las chaperonas tienen un rol clave en esto. BiP (Por sus siglas in inglés
Immunoglobulin Binding Protein) es un ...
Abnormal calcium homeostasis and proteinfolding stress at the ER: A common factor in familial and infectious prion disorders
(2011)
Prion-related disorders (PrDs) are caused by the accumulation of a misfolded and protease-resistant form of the cellular prion, leading to neuronal dysfunction and massive neuronal loss. In humans, PrDs have distinct ...
Microtubule organization in normal cells and disease: The housekeeping role of heat-shock proteins and immunophilins
(Nova Science Publishers, 2012)
Cytoskeleton is the basic scaffold of the cell in which other subcellular components are spatially arranged, such that they are able to communicate efficiently between the internal and external environments of the cell. ...
Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
(Bentham Science Publishers, 2011-05)
Control of protein synthesis and quality are critical steps to support eukaryotic cells’ maintenance and survival. Two very distinctive mechanisms emerge as key checkpoints of protein synthesis regulation. The first one ...
CIMMYT Report 1966-67
(CIMMYT, 2012)
Disaggregases, Molecular Chaperones That Resolubilize Protein Aggregates
(ACAD BRASILEIRA DE CIENCIASRIO JANEIRO, 2015)
Interplay between the oxidoreductase pdia6 and microrna-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis
(AMER ASSOC ADVANCEMENT SCIENCE, 2014)
The disruption of the energy or nutrient balance triggers endoplasmic reticulum (ER) stress, a process that mobilizes various strategies, collectively called the unfolded protein response (UPR), which reestablish homeostasis ...