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Host pharmacokinetics and drug accumulation of anthelmintics within target helminth parasites of ruminants
(New Zealand Veterinary Assoc Inc, 2017-07)
Anthelmintic drugs require effective concentrations to be attained at the site of parasite location for a certain period to assure their efficacy. The processes of absorption, distribution, metabolism and excretion ...
Efeitos do tratamento oral com sulfato de vanadila em ratos diabeticos jovens
(1998-12-01)
This work intends to evaluate the effects of oral vanadyl treatment (VOSO 4, 1 mg/mL) in young streptozotocin-diabetic rats during 19 and 29 days. In several times of treatment the rats were monitored to determine body ...
Pharmacokinetics of hydroxymethylnitrofurazone and its parent drug nitrofurazone in rabbits
(2013-01-01)
The prodrug hydroximethylnitrofurazone (NFOH) presents antichagasic activity with greatly reduced toxicity compared to its drug matrix nitrofurazone (NF). Besides these new characteristics, the prodrug was more active ...
Release of formaldehyde by 4 endodontic sealers
(1999-12-01)
Objective. The purpose of this study was to evaluate the release of formaldehyde by some root canal filling materials. Study design. Two older endodontic sealers, AH 26 and Endomethasone, and 2 recently available sealers, ...
Innovative Mucoadhesive Precursor of Liquid Crystalline System Loading Anti-Gellatinolytic Peptide for Topical Treatment of Oral Cancer
(Amer Scientific Publishers, 2021-02-01)
Current researches report an actual benefit of a treatment for oral cancer via inhibition of proteolytic matrix metalloproteinases (MPP) with a peptide drug, called CTT1. However, peptides present poor oral bioavailability. ...
Design of mucoadhesive gellan gum and chitosan nanoparticles intended for colon-specific delivery of peptide drugs
(2021-11-05)
Nanotechnology has been widely used in the development of polymer nanocarriers for the oral delivery of biomolecules. The use of nanostructured systems can improve drug delivery and help to overcome the disadvantages of ...
Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Studies have suggested a relationship between drug abuse and compulsive behaviors. The present experiments investigated the relationship between schedule-induced polydipsia (SIP) and self-administration (SA) of ethanol and ...
Nanotechnological delivery systems for the oral administration of active molecules: Polymeric microparticles and microemulsions applied to anti-inflammatory and anti-infectious drugs
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em Ciências da SaúdeCiências da Saúde, 2013-04-05)
This thesis was devoted to the development of innovative oral delivery systems for two
different molecules. In the first part, microparticles (MPs) based on xylan and Eudragit® S-
100 were produced and used to encapsulate ...