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Characterization and trypanocidal activity of nifurtimox-containing and empty nanoparticles of polyethylcyanoacrylates
(ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, 1998)
The aim of this study was to evaluate the utility of nanoparticles of polyalkylcyanoacrylate as a targeted delivery system for nifurtimox against Trypanosoma cruzi, responsible for Chagas' disease. Ethylcyanoacrylate ...
Chagas disease: Present status of pathogenic mechanisms and chemotherapy
(Sociedad de Biología de Chile, 2010)
Disposition of Nifurtimox and Metabolite Activity Against Trypanosoma cruzi using Rat Isolated Perfused Liver
(1994)
Abstract— Nifurtimox disposition was investigated using the rat isolated perfused‐liver method after administration of 25 μg mL−1 nifurtimox, and its disappearance was monitored by analysing the perfusate sample at various ...
Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review
(Elsevier Science, 2019-10)
Neglected tropical diseases (NTDs) constitute a group of infectious diseases prevalent in countries with tropical and subtropical climate that affect the poorest individuals and produce high chronic disability associated ...
Terapêutica da fase crônica da infecção experimental pelo Trypanosoma cruzi com o benzonidazole o nifurtimox
(Sociedade Brasileira de Medicina Tropical, 2016)
Current and developing therapeutic agents in the treatment of Chagas disease
(2010)
Chagas disease must be treated in all its stages: acute, indeterminate, chronic, and initial and middle determinant chronic, due to the fact that DNA of the parasite can be demonstrated by PCR in chronic cases, where optical ...
Treatment of Chagas disease
(Elsevier, 2017)
Although Chagas disease has existed for at least 9000 years, its treatment is recent: the internationally accepted drugs nifurtimox and benznidazole date from the 1970s. Both drugs are effective in acute cases, in congenital ...
Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of Nifurtimox and Benznidazole
(Sage Publications Ltd, 2013-12)
Nifurtimox (Nfx) and benznidazole (Bz) have serious toxic side effects. Manufacturers warn about significant adverse effects when simultaneous alcohol consumption is being made, but its mechanism is not known. The levels ...
Reactions of Nifurtimox with critical sulfhydryl-containing biomolecules: Their potential toxicology relevance
(John Wiley & Sons Ltd, 2004-05)
Nifurtimox (Nfx) is a drug used in the treatment of Chagas' disease, an endemic parasitic disease from Latin American countries. It produces undesirable side-effects in patients, frequently forcing the treatment to be ...