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Excitotoxicity as a target against neurodegenerative processes
(Bentham Science Publishers, 2020)
The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia
(Frontiers Media S.A., 2019)
Design e síntese de derivados da retronecina e avaliação da atividade in vivo no modelo de Caenorhabditis elegans para a doença de alzheimer
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS, 2018-02-27)
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease and the most common
form of dementia in the elderly worldwide. Pathological characteristics of AD include
amyloid beta (Aβ) plaques, neurofibrillary ...
Pharmacological modulation of cognitive and behavioral symptoms in patients with dementia due to Alzheimer's disease
(Elsevier B.V., 2014-01-15)
To evaluate correlations of pharmacological treatment with cognitive and behavioral symptoms in patients with dementia due to Alzheimer's disease with low schooling, subjects were assessed for demographic features, ...
Evaluation of [18F] FNM biodistribution and dosimetry based on whole-body PET imaging of rats
(2018)
Introduction: The aim of this work was to study the biodistribution, metabolism and radiation dosimetry of rats
injected with [18F]FNM using PET/CT images. This novel radiotracer targeting NMDA receptor has potential ...
Determinación en membranas celulares y modelos moleculares del efecto protector de drogas utilizadas en la enfermedad de Alzheimer.Determination in cell membranes and molecular models of the protective effect of drugs used in Alzheimer's disease.
(2019)
El péptido beta amiloide (Aβ) es tóxico para las neuronas. Desde hace más de una década se han examinado los efectos de medicamentos que tienen una acción inhibidora de la acetilcolinesterasa, con lo cual se han mejorado ...
Inhibition of the α9α10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-d-aspartate receptors
(Elsevier Science, 2007-07)
In this study we report the effects of neramexane, a novel amino-alkyl-cyclohexane derivative that is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, on recombinant rat α9α10 nicotinic acetylcholine ...
New treatment strategies for Alzheimer's disease: Is there a hope?
(2013-10-01)
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, and corresponds to the most common cause of dementia worldwide. Although not fully understood, the pathophysiology of AD is largely ...