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Autophagy is associated with male sterility in pistillate flowers of Maytenus obtusifolia (Celastraceae)
(Csiro Publishing, 2018-01-01)
Programmed cell death (PCD) is defined as a sequence of genetically regulated events leading to controlled and organised cellular degradation. It plays a vital role in plant development; however, little is known about the ...
XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy
(Taylor and Francis Inc., 2009)
Endoplasmic reticulum (ER) stress has been extensively described in many protein misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is mediated by the activation of an integrated ...
The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores aminochrome induced mitochondrial damage
(American Chemical Society, 2017)
Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...
The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores aminochrome-induced mitochondrial damage
(American Chemical Society, 2017)
Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...
Late-in-life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts
(2021-01-01)
Protein quality control mechanisms decline during the process of cardiac aging. This enables the accumulation of protein aggregates and damaged organelles that contribute to age-associated cardiac dysfunction. Macroautophagy ...
Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis
(BioMed Central, 2012)
Abstract
Background
Propolis is a natural product of plant resins collected by honeybees (Apis mellifera) from various plant ...
Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis
(2012-10-24)
Abstract
Background
Propolis is a natural product of plant resins collected by honeybees (Apis mellifera) from various plant sources. Our previous studies indicated that ...
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
(NATURE PUBLISHING GROUP, 2009-07)
The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca2+) transients from the endoplasmic ...
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
(2009)
Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress in the disease process via a pathway known ...
Induction of autophagy increases the proteolytic activity of reservosomes during Trypanosoma cruzi metacyclogenesis
(Landes Bioscience, 2020-02)
Cruzipain, the major cysteine protease of the pathogenic protozoa Trypanosoma cruzi, is an important virulence factor that plays a key role in the parasite nutrition, differentiation and host cell infection. Cruzipain is ...