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Carbohydrate-binding proteins: dissecting ligand structures through solvent environment occupancy
(American Chemical Society, 2009-06)
Formation of protein ligand complexes is a fundamental phenomenon in biochemistry. During the process, significant solvent reorganization is produced along the contact surface and many water molecules strongly bound to the ...
Helix 12 Dynamics and Thyroid Hormone Receptor Activity: Experimental and Molecular Dynamics Studies of Ile280 Mutants
(Academic Press Ltd- Elsevier Science LtdLondonInglaterra, 2011)
Presence of estrogen receptor (ER)-like proteins and endogenous ligands for ER in solanaceae
(Elsevier Ireland, 2004-12)
The synthesis of steroid hormones in different plant species and the possibility that these molecules could regulate cell growth, tissue differentiation and germination has been reported. However, the mechanism of action ...
Mapping eIF5A binding sites for Dys1 and Lia1: In vivo evidence for regulation of eIF5A hypusination
(2003-12-18)
The evolutionarily conserved factor eIF5A is the only protein known to undergo hypusination, a unique posttranslational modification triggered by deoxyhypusine synthase (Dys1). Although eIF5A is essential for cell viability, ...
Mapping eIF5A binding sites for Dys1 and Lia1: In vivo evidence for regulation of eIF5A hypusination
(2003-12-18)
The evolutionarily conserved factor eIF5A is the only protein known to undergo hypusination, a unique posttranslational modification triggered by deoxyhypusine synthase (Dys1). Although eIF5A is essential for cell viability, ...
Small-Molecule Ligands that bind the RET receptor activate neuroprotective signals independent of but modulated by coreceptor GFR α 1
(American Society for Pharmacology and Experimental Therapeutics, 2020-08)
Glial cell line-derived neurotrophic factor (GDNF) binds the GFRα1 receptor, and the GDNF-GFRα1 complex binds to and activates the transmembrane RET tyrosine kinase to signal through intracellular Akt/Erk pathways. To ...
Allosteric Pathways In The Ppar Gamma-rxr Alpha Nuclear Receptor Complex
(NATURE PUBLISHING GROUPLONDON, 2016)
On the analysis and comparison of conformer-specific essential dynamics upon ligand binding to a protein
(American Institute of Physics, 2015-06)
The native state of a protein consists of an equilibrium of conformational states on an energy landscape rather than existing as a single static state. The co-existence of conformers with different ligand-affinities in a ...