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Ligand screening assay for the enzyme kallikrein immobilized on NHS-activated Sepharose
(Elsevier B.V., 2021-05-30)
Human tissue kallikreins (KLKs) are serine proteases involved in various physiological and pathological conditions, including cancer and neurological disorders. These enzymes constitute attractive drug targets, which has ...
PLASMA KALLIKREIN and THROMBIN ARE CLEARED THROUGH UNRELATED HEPATIC PATHWAYS
(Rapid Science Publishers, 1993-08-01)
Plasma kallikrein (PK) and thrombin (TH), serine proteinases formed from inactive precursors, participate in important body defence mechanisms. the isolated hepatocyte recognizes TH, and the liver clears PK by calcium-independent ...
Novel anti-thrombotic mechanisms mediated by mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems
The risk of thrombosis, a globally growing challenge and a major cause of death, is influenced by
various factors in the intravascular coagulation, vessel wall, and cellular systems. Among the
contributors to thrombosis, ...
Plasma kallikrein enhances platelet aggregation response by subthreshold doses of ADP
(Elsevier B.V., 2017-04-01)
Human plasma kallikrein (huPK) potentiates platelet responses to subthreshold doses of ADP, although huPK itself, does not induce platelet aggregation. In the present investigation, we observe that huPK pretreatment of ...
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
(Elsevier B.V., 2013-04-12)
Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of ...
Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene
(Federation Amer Soc Exp Biol, 2004-05-01)
Diabetic cardiomyopathy includes fibrosis. Kallikrein (KLK) can inhibit collagen synthesis and promote collagen breakdown. We investigated cardiac fibrosis and left ventricular (LV) function in transgenic rats (TGR) ...
Human plasma kallikrein. Preliminary studies on hydrolysis of proteins and peptides
(Birkhauser Verlag Ag, 1978-01-01)
Acid-activated human plasma kallikrein (HuPK) was purified from human Cohn fraction IV by affinity chromatography, using as ligand soybean trypsin inhibitor and aminobenzamidine. The purified enzyme does not inactivate ...
Protective actions of human tissue kallikrein gene in transgenic rat hearts
(Elsevier B.V., 2008-02-01)
In this study, we used an experimental model. of cardiac hypertrophy to explore the role of the kallikrein-kinin system (KKS) in cardiac protection in transgenic rats harboring the human tissue kallikrein gene, TGR(hKLK1). ...