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Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
(Elsevier B.V., 1995-12-27)
The presence of tyrosine-phosphorylated proteins was studied in cultured rat pancreatic islets, Immunoblotting performed with total extracts of islets cultured in the presence of 1.8 or 5.6 mM glucose revealed at least ...
Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
(Elsevier B.V., 1995-12-27)
The presence of tyrosine-phosphorylated proteins was studied in cultured rat pancreatic islets, Immunoblotting performed with total extracts of islets cultured in the presence of 1.8 or 5.6 mM glucose revealed at least ...
Periapical lesions decrease insulin signal and cause insulin resistance
(2013-05-01)
Introduction: Inflammatory cytokines are associated with decreased insulin signal transduction. Moreover, local oral inflammation, such as that accompanying periodontal disease, is associated with insulin resistance and ...
Periapical lesions decrease insulin signaling in rat skeletal muscle
(Elsevier B. V., 2015)
Serum inflammatory cytokines derived from oral inflammation are associated with decreased insulin signaling (IS) and insulin resistance, which is a major risk factor for type 2 diabetes mellitus. This study aimed to ...
The effects of aging on rho-kinase and insulin signaling in skeletal muscle and white adipose tissue of rats
(2020-02-14)
The insulin receptor substrate 1 regulates insulin-mediated glucose uptake and is a target of Rho-kinase (Rock); however, the relationship between age-related insulin resistance and Rock signaling specifically in skeletal ...
Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B
(Biomed Central, 2013-03-11)
Insulin and insulin-like growth factors (IGFs) act on tetrameric tyrosine kinase receptors controlling essential functions including growth, metabolism, reproduction and longevity. The insulin receptor (IR) binds insulin ...
Antidiabetic potential of saffron and its active constituents
(Wiley-Liss Inc., 2019)