Buscar
Mostrando ítems 31-40 de 345
The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons
(2015)
Wnt signaling regulates synaptic development and function and contributes to the fine-tuning of the molecular and morphological differentiation of synapses. We have shown previously that Wnt5a activates non-canonical Wnt ...
Frizzled-1 receptor regulates adult hippocampal neurogenesis
(2016)
Background: In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt signaling, which plays a ...
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2þ release without affecting endoplasmic reticulum Ca2þ content in primary hippocampal neurons
(Elsevier, 2015)
Ryanodine is a cell permeant plant alkaloid that binds selectively and with high affinity to ryanodine
receptor (RyR) Ca2þ release channels. Sub-micromolar ryanodine concentrations activate RyR channels
while micromolar ...
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons
(Academic Press, 2015)
Ryanodine is a cell permeant plant alkaloid that binds selectively and with high affinity to ryanodine
receptor (RyR) Ca2þ release channels. Sub-micromolar ryanodine concentrations activate RyR channels
while micromolar ...
Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
(2010)
Abstract
Background
Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ ...
Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons
(2016)
Abstract
Background
Wnt-5a is a member of the WNT family of secreted lipoglycoproteins, whose expression increases during development; moreover, Wnt-5a plays a key role in ...
Inhibition of tau phosphorylating protein kinase cdk5 prevents β-amyloid-induced neuronal death
(1999)
The key target of this study was the tau protein kinase II system (TPK II) involving the catalytic subunit cdk5 and the regulatory component p35. TPK II is one of the tau phosphorylating systems in neuronal cells, thus ...
Sab is differentially expressed in the brain and affects neuronal activity
(Elsevier, 2017)
Abstract: Sab (SH3 binding protein 5 or SH3BP5) is a mitochondrial scaffold protein involved in signaling associated with mitochondrial dysfunction and apoptosis; furthermore, Sab is a crucial signaling platform for ...
Ketamine Increases the Function of γ-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons
(Lippincott Williams and Wilkins, 2017)
© 2016, the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc. All Rights Reserved.Background: The dissociative general anesthetic ketamine is a well-known N-methyl-d-aspartate receptor antagonist. ...
Astrocyte-derived small extracellular vesicles regulate dendritic complexity through miR-26a-5p activity
(MDPI, 2020)
In the last few decades, it has been established that astrocytes play key roles in the regulation of neuronal morphology. However, the contribution of astrocyte-derived small extracellular vesicles (sEVs) to morphological ...