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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
(2010)
Abstract
Background
Collybistin (CB), a neuron-specific guanine nucleotide exchange factor, has been implicated in targeting gephyrin-GABAA receptors clusters to inhibitory postsynaptic sites. However, little is ...
Caracterização funcional da região promotora do gene Rasgef1b e avaliação de componentes da via de sinalização de receptores do tipo toll (TLRs)
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2016-02-19)
The guanine nucleotide exchange factor RasGEF1b is encoded by a gene whose expression is induced in innate immune cells in response to the activation of Toll-like receptors (TLRs). RasGEF1b mRNA levels are increased in ...
Rab-mediated trafficking role in neurite formation
(International Society for Neurochemistry, 2014)
Neuronal cells are characterized by the presence of two
confined domains, which are different in their cellular properties,
biochemical functions and molecular identity. The generation
of asymmetric domains in neurons ...
Superoxide generation via the NR2B-NMDAR/RasGRF1/NOX2 pathway promotes dendritogenesis.
(2019)
N-methyl-D-aspartate receptors (NMDARs) that contain the NR2A and NR2B subunits play a critical role in neuronal plasticity and dendritogenesis. Gain-and-loss-of function studies indicate that NR2B, but not NR2A, promotes ...
Aβ1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases
(2007)
A number of psychiatric and neurodegenerative disorders, such as Alzheimer's disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced by ...
Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association
(American Society for Cell Biology, 2007-07)
Assembly of the cytosolic coat protein I (COPI) complex at the ER-Golgi interface is directed by the ADP ribosylation factor1 (Arf1) and its guanine nucleotide exchange factor (GBF1). Rab1b GTPase modulates COPI recruitment, ...