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In silico identification of immunotherapeutic and diagnostic targets in the glycosylphosphatidylinositol metabolism of the coccidian Sarcocystis aucheniae
(Wiley, 2020-07)
Meat of the South American camelids (SACs) llama and alpaca is an important source of animal protein and income for rural families in the Andes, and a product with significant growth potential for local and international ...
EXPRESSION OF MYCOBACTERIUM-LEPRAE 18-KDA ANTIGEN IN YEAST IN A GPI-ANCHORED FORM
(Assoc Bras Divulg Cientifica, 1994-03-01)
The 18-kDa protein from Mycobacterium leprae is a major target for the immune response in leprosy. We have developed a system to express this antigen in yeast as a fusion protein with the C-terminal region of the yeast ...
Vaccination against babesiosis using recombinant GPI-anchored proteins
(Elsevier, 2019-01)
The increase in human babesiosis is of major concern to health authorities. In the USA, most of these cases are due to infections with Babesia microti, whereas in Europe B. divergens is the major cause of clinical disease ...
Glicosilfosfatidilinositol como alvo terapêutico e vacinal contra doenças parasitárias intracelularesGlycosylphosphatidylinositol as a therapeutic and vaccine target against intracellular parasitic diseases
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Imunologia e Parasitologia Aplicadas, 2021)
CHARACTERIZATION OF A PHOSPHOLIPASE C-RESISTANT INOSITOL CONTAINING GLYCOLIPID FROM TRYPANOSOMA-CRUZI
(Assoc Bras Divulg Cientifica, 1994-02-01)
Since glycosylphosphatidylinositol is the most common form of attachment of proteins to membranes in T. cruzi, and that this parasite depends on surface-mediated interactions for survival within the vector and mammalian ...
The GPI-anchored 6-Cys Protein Pv12 is Present in Detergent-resistant Microdomains of Plasmodium vivax Blood Stage Schizonts
Plasmodium vivax malaria remains one of the tropical diseases causing an enormous burden on global public health. Several proteins located on this parasite species' merozoite surface have been considered the most suitable ...
Acquisition and biosynthesis of saturated and unsaturated fatty acids by trypanosomatids
(Elsevier Science, 2014-04)
As components of phospholipids and glycosylphosphatidylinositol anchors, fatty acids are responsible for forming the core of biological membranes and the correct localization of proteins within membranes. They also contribute ...
Conserved high activity binding peptides are involved in adhesion of two detergent-resistant membrane-associated merozoite proteins to red blood cells during invasion
Detergent resistant membranes (DRMs) of Plasmodium falciparum merozoites contain a large number of glycosylphosphatidylinositol (GPI)-anchored proteins that have been implicated in interactions between merozoites and red ...
Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite
(Elsevier, 2011-09)
A dense glycocalix covers the surface of Trypanosoma cruzi, the agent of Chagas disease. Sialic acid in the surface of the parasite plays an important role in the infectious process, however, T. cruzi is unable to synthesize ...
Characterization of GASA-1, a new vaccine candidate antigen of Babesia bovis
(Elsevier, 2020-11)
Surface proteins bound to the cell membrane by glycosylphosphatidylinositol (GPI) anchors are considered essential for the survival of pathogenic protozoans. In the case of the tick-transmitted hemoparasite Babesia bovis, ...