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Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1
(BioScientifica Ltd, 2013-12)
Inflammatory responses are elicited after injury, involving release of inflammatory mediators that ultimately lead, at the molecular level, to the activation of specific transcription factors (TFs; mainly activator protein ...
Differential regulation of the glucocorticoid receptor nucleocytoplasmic shuttling by TPR-domain proteins
(Elsevier Science, 2021-05)
A dimer of the heat-shock protein of 90-kDa (Hsp90) represents the critical core of the chaperone complex associated to the glucocorticoid receptor (GR) oligomer. The C-terminal end of the Hsp90 dimer shapes a functional ...
Mecanismos moleculares de regulación de la sensibilidad a glucocorticoides por las citoquinasMolecular mechanisms of glucocorticoid sensetivity regulation by cytokines
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 1996)
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
(Taylor, 2017-01-08)
It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the ...
Glucocorticoid Receptor-α and MKP-1 as Candidate Biomarkers for Treatment Response and Disease Activity in Vogt-Koyanagi-Harada Disease
(Elsevier Inc, 2019)
Purpose
To investigate the potential of utilizing the expression of genes for glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase-1 (MKP-1) as biomarkers of corticosteroid (CS) refractoriness and ...
Effect of glucocorticoids on androgen biosynthesis in the testes of the toad Rhinella arenarum (Amphibia, Anura)
(John Wiley & Sons Inc, 2018-12)
In rat Leydig cells, glucocorticoids (GCs) inhibit testosterone production through the interaction with the glucocorticoid receptor (GR). However, the sensitivity of those cells to GCs is regulated by the enzyme ...
Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes
(Endocrine Society, 2006-11-11)
The antiapoptotic effect of melatonin (MEL) has been described in several systems. In particular, MEL inhibits glucocorticoid-mediated apoptosis. Our group previously demonstrated that in the thymus, MEL inhibits the release ...
Retrograde transport of the GR requires dynamic assembly of complexes with hsp90 and is linked to the CHIP component of the proteosome
(Elsevier, 2004-12)
Here, we have used a chimera of green fluorescent protein (GFP) and the glucocorticoid receptor (GR) to study retrograde movement of a model soluble (i.e., non-vesicle-associated) protein in axons and dendrites of cultured ...
Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells
(Elsevier Science, 2020-01)
Targeting the apoptosis machinery is a promising therapeutic approach in myeloid malignancies. BCL2L1 is a well-known glucocorticoid-responsive gene and a key apoptosis regulator that, when over-expressed, can contribute ...
DNA binding triggers tetramerization of the glucocorticoid receptor in live cells
(National Academy of Sciences, 2016-07)
Transcription factors dynamically bind to chromatin and are essential for the regulation of genes. Although a large percentage of these proteins appear to self-associate to form dimers or higher order oli gomers, t he ...