Buscar
Mostrando ítems 31-40 de 108
Structure and dynamics of neurosteroid binding to the α1β2γ2 GABAA receptor
(Pergamon-Elsevier Science Ltd, 2018-09-01)
Neurosteroids are the principal endogenous modulators of the γ-Aminobutyric acid receptors (GABAARs), pentameric membrane-bound proteins that can be assembled from at least 19 subunits. In the most abundant GABAAR arrangement ...
Flavonoids as GABAA receptor ligands: the whole story?
(Dove Medical Press, 2012-01)
Benzodiazepines are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side effects that they produce, such as sedation, myorelaxation, ataxia, amnesia, and ...
Presynaptic Effects of N-Methyl-D-Aspartate Receptors Enhance Parvalbumin Cell–Mediated Inhibition of Pyramidal Cells in Mouse Prefrontal Cortex
(Elsevier Science Inc, 2018-09)
Background: Testing hypotheses regarding the role of N-methyl-D-aspartate receptor (NMDAR) hypofunction in schizophrenia requires understanding the mechanisms of NMDAR regulation of prefrontal cortex (PFC) circuit function. ...
Potential use of melatonergic drugs in analgesia: Mechanisms of action
(Pergamon-Elsevier Science Ltd, 2010-03)
Melatonin is a remarkable molecule with diverse physiological functions. Some of its effects are mediated by receptors while other, like cytoprotection, seem to depend on direct and indirect scavenging of free radicals not ...
Potential use of melatonergic drugs in analgesia : mechanisms of action
(Elsevier, 2010)
abstract: Melatonin is a remarkable molecule with diverse physiological functions. Some of its effects are mediated by receptors while other, like cytoprotection, seem to depend on direct and indirect scavenging of free ...
Ontogenic expression of anterior pituitary GABAB receptor subunits
(Pergamon-Elsevier Science Ltd., 2001)
gamma-Aminobutyric acid (GABA) is involved in the neuroendocrine control of hypophyseal secretion, acting both in the central nervous system and directly at the pituitary. We have characterized the properties of anterior ...
GABAergic Regulation of Astroglial Gliotransmission through Cx43 Hemichannels
(2022)
Gamma-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. It is produced by interneurons and recycled by astrocytes. In neurons, GABA activates the influx of Cl- via the GABAA receptor or ...
GABAergic Regulation of Astroglial Gliotransmission through Cx43 Hemichannels
(MDPI, 2022-11)
Gamma-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. It is produced by interneurons and recycled by astrocytes. In neurons, GABA activates the influx of Cl- via the GABAA receptor or ...
A transcriptional study in mice with different ethanol-drinking profiles: Possible involvement of the GABA(B) receptor
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Previous studies have suggested that gamma-aminobutyric acid-B (GABA(B)) receptor agonists effectively reduce ethanol intake. The quantification using real-time polymerase chain reaction of Gabbr1 and Gabbr2 mRNA from the ...