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Factors influencing the prevalence of resistance-associated substitutions in NS5A protein in treatment-naive patients with chronic hepatitis C
(MDPI, 2020-04)
Direct-acting antivirals (DAAs) revolutionized treatment of hepatitis C virus (HCV) infection. Resistance-associated substitutions (RASs) present at the baseline impair response to DAA due to rapid selection of resistant ...
Analysis of the Interaction Interfaces of the N-Terminal Domain from Pseudomonas aeruginosa MutL
(Public Library Science, 2013-07-26)
Mismatch Repair System corrects mutations arising from DNA replication that escape from DNA polymerase proofreadingactivity. This system consists of three main proteins, MutS-L-H, responsible for lesion recognition and ...
Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles
(IOP Publishing, 2019-01)
The membrane pore-forming activities of the antimicrobial peptide GWH1 have been evaluated in combination with the CXCR4-binding properties of the peptide T22, in self-assembling protein nanoparticles with high clinical ...
Expression of calcium-buffering proteins in rat intrinsic laryngeal muscles
(Wiley-Blackwell, 2015-06-01)
Intrinsic laryngeal muscles (ILM) are highly specialized muscles involved in phonation and airway protection, with unique properties that allow them to perform extremely rapid contractions and to escape from damage in ...
Transgene escape and persistence in an agroecosystem: the case of glyphosate-resistant Brassica rapa L. in central Argentina
(Springer, 2017-12-14)
Brassica rapa L. is an annual Brassicaceae species cultivated for oil and food production, whose wild form is a weed of crops worldwide. In temperate regions of South America and especially in the Argentine Pampas region, ...
Endogenous Galectin-1 in T Lymphocytes Regulates Anti-prostate Cancer Immunity
(Frontiers Research Foundation, 2018-09)
The identification of effective new therapies for prostate cancer (PCa) requires a better understanding of the multiple molecular interactions between tumor cells and their associated microenvironment. In this context, ...
Intrinsically disordered proteins (IDPs) in trypanosomatids
(BioMed Central, 2022)
SARS-CoV-2 vaccines: evolution and escapeVacunas SARS-CoV-2: evolución y escape
(Universidad de Córdoba, 2021)