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A fragment-based approach for the in silico prediction of blood-brain barrier permeation
(Sociedade Brasileira de Química, 2012)
Blood-brain barrier (BBB) permeation is an essential property for drugs that act in the central nervous system (CNS) for the treatment of human diseases, such as epilepsy, depression, Alzheimer's disease, Parkinson disease, ...
Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System
(Pergamon-Elsevier Science Ltd, 2019-05)
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by ...
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
(2017-01-07)
Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, ...
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants
(Elsevier, 2017)
Background: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, ...
Dietary, anthropometric, and biochemical determinants of uric acid in free-living adults
(2013-01-16)
Background: High plasma uric acid (UA) is a prerequisite for gout and is also associated with the metabolic syndrome and its components and consequently risk factors for cardiovascular diseases. Hence, the management of ...
Dietary, anthropometric, and biochemical determinants of uric acid in free-living adults
(2013-01-16)
Background: High plasma uric acid (UA) is a prerequisite for gout and is also associated with the metabolic syndrome and its components and consequently risk factors for cardiovascular diseases. Hence, the management of ...
Blood-brain barrier breakdown following gliotoxic drug injection in the brainstern of Wistar rats
(Assoc Arquivos De Neuro- PsiquiatriaSao Paulo SpBrasil, 2002)
Central Blood Pressure Waves Assessment: A Validation Study of Non-invasive Aortic Pressure Measurement in Human Beings
(Springer, 2020-04)
Introduction: Measurement of central (aortic) systolic blood pressure has been shown to provide reliable information to evaluate target organ damage. However, non-invasive central blood pressure measurement procedures are ...
O óxido nítrico (NO) no controle neural da pressão arterial: Modulação da transmissão glutamatérgica no NTS
(2006-01-01)
The neuromodulatory effect of nitric oxide (NO) on glutamatergic transmission within the NTS related to cardiovascular regulation has been widely investigated. Activation of glutamatergic receptors in the NTS stimulates ...