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Neonatal exposure to estradiol valerate reprograms the rat ovary androgen receptor and anti-Müllerian hormone to a polycystic ovary phenotype
(Elsevier INC, 2018)
To understand the impact of exposure to steroids in the early step of ovary development(a stage occurring
in uterus in humans), we studied neonatal exposure to estradiol valerate (EV) in rats regarding polycystic
ovary ...
Neonatal exposure to estradiol valerate reprograms the rat ovary androgen receptor and anti-Müllerian hormone to a polycystic ovary phenotype
(Elsevier Inc., 2018)
© 2017 Elsevier Inc. To understand the impact of exposure to steroids in the early step of ovary development (a stage occurring in uterus in humans), we studied neonatal exposure to estradiol valerate (EV) in rats regarding ...
Nuclear loss and cytoplasmic expression of androgen receptor in penile carcinomas: role as a driver event and as a prognosis factor
(2018-01-01)
Androgen receptor (AR) is a member of the steroid and nuclear family receptor that acts as transcription factor. AR signaling plays pivotal role in the development and progression of prostate cancer. However, the role of ...
Modulation of inflammatory and hormonal parameters in response to testosterone therapy: Effects on the ventral prostate of adult rats
(Wiley-Blackwell, 2018-09-01)
Testosterone is often recommended in the treatment of several aging-related conditions. However, there are still questions about the consequences of this therapy in terms of hormonal and inflammatory parameters that are ...
Increased expression of ACTH (MC2R) and androgen (AR) receptors in giant bilateral myelolipomas from patients with congenital adrenal hyperplasia
(BioMed Central, 2014)
Abstract
Background
Although chronic adrenocorticotropic hormone (ACTH) and androgen hyperstimulation are assumed to be involved in the pathogenesis of adrenal myelolipomas ...
Effects of castration on androgen receptors and gonadotropins in the pituitary of adult male viscachas
(Csiro Publishing, 2014-08)
The aims of the present study were to determine whether castration results in quantitative immunohistochemical changes in androgen receptors (AR), LH-immunoreactive (IR) cells and FSH-IR cells, and to analyse the colocalisation ...
Novel androgen-induced activity of an antimicrobial beta-defensin: Regulation of Wolffian duct morphogenesis
(Elsevier Ireland Ltd, 2017)
The Wolffian duct (WD) undergoes morphological changes induced by androgens to form the epididymis, which is an organ essential for sperm maturation. Androgen action in WD epithelium involves paracrine factors of mesenchymal ...
Hair follicle stem cell differentiation is inhibited through cross-talk between Wnt/β-catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia
(Wiley Blackwell Publishing, Inc, 2012-05)
Background Hair follicle (HF) regeneration begins when signals from the mesenchyme-derived dermal papilla cells (DPC) reach multipotent epidermal stem cells in the bulge region. Wnt/β-catenin signalling is known to affect ...
Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces
(Wiley, 2017-07)
Besides their development for therapeutic purposes, non-steroidal selective androgen receptormodulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). ...