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Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats
(WILEY, 2009)
Up regulation of the transforming growth factor-beta 1 (TGF-beta 1) axis has been recognized as a pathogenic event for progression of glomerulosclerosis in diabetic nephropathy. We demonstrate that glomeruli isolated from ...
Adenosine and preeclampsia
(2017)
Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological processes including circulation, renal blood flow, immune function, or glucose homeostasis. Changes in adenosine membrane transporters, ...
The potentiation of the histamine release induced by adenosine in mast cells from guinea pig lung and heart: Sharp dependence on the time of preincubation
(Academic Press Ltd, 2000-03-01)
We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3) M) potentiated ...
The potentiation of the histamine release induced by adenosine in mast cells from guinea pig lung and heart: Sharp dependence on the time of preincubation
(Academic Press Ltd, 2000-03-01)
We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3) M) potentiated ...
Structural determinants of efficacy at A3 adenosine receptors: Modification of the ribose moiety
(Pergamon-Elsevier Science Ltd, 2004-03)
We have found previously that structural features of adenosine derivatives, particularly at the N6- and 2-positions of adenine, determine the intrinsic efficacy as A3 adenosine receptor (AR) agonists. Here, we have probed ...
Negative chronotropic response to adenosine receptor stimulation in rat right atria after run training
(Blackwell Publishing Asia, 2004-10-01)
The aim of the present study was to evaluate the potency and maximal responses (E-max) to the adenosine receptor agonists N-6-cyclopentyladenosine (CPA), N-ethylcarboxamidoadenosine (NECA) and N-6-(3-iodobenzyl)-5'-N-met ...
Molecular Implications Of Adenosine In Obesity
(2017)
Adenosine has broad activities in organisms due to the existence of multiple receptors, the differential adenosine concentrations necessary to activate these receptors and the presence of proteins able to synthetize, degrade ...
Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells
(Impact Journals LLC, 2016)
MRP1 transporter correlates positively with glioma malignancy and the Multiple Drug Resistance (MDR) phenotype in Glioblastoma Multiforme (GBM). Evidence shows that the MRP1 transporter is controlled by the adenosine ...