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Clinical features and genetic analysis of four Brazilian kindreds with resistance to thyroid hormone
(Blackwell Publishing, 2007-11-01)
Objective Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome of reduced tissue responsiveness to thyroid hormone usually due to mutations located in the ligand-binding domain and adjacent hinge region ...
Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α
(National Academy of Sciences, 2013-05)
Genetic evidence from patients with mutations of the thyroid hormone receptor α gene (THRA) indicates that the dominant negative activity of mutants underlies the pathological manifestations. However, the molecular mechanisms ...
Genotyping of resistance to thyroid hormone in South American population. Identification of seven novel missense mutations in the human thyroid hormone receptor β gene
(Academic Press Ltd - Elsevier Science Ltd, 2009-06)
Thyroid Hormone Receptor β (THRB) defects, typically transmitted as autosomal dominant traits, cause Resistance to Thyroid Hormone (RTH). We analyzed the THRB gene in thirteen South American patients with clinical evidence ...
Combined effects of transferrin and thyroid hormone during oligodendrogenesis In vitro
(Wiley, 2016-07)
Thyroid hormones (THs) and transferrin (Tf) are factors capable of favoring myelination due to their positive effects on oligodendroglial cell (OLG) differentiation. The first notion of a combined effect of apotransferrin ...
The role of thyroid hormone calorigenesis in the redox regulation of gene expression
(Sociedad de Biología de Chile, 2006)
Profile of thyroid hormones in breast cancer patients
(Associação Brasileira de Divulgação Científica (ABRADIC), 2005-05-01)
Estrogen involvement in breast cancer has been established; however, the association between breast cancer and thyroid diseases is controversial. Estrogen-like effects of thyroid hormone on breast cancer cell growth in ...
Profile of thyroid hormones in breast cancer patients
(Associação Brasileira de Divulgação Científica (ABRADIC), 2005-05-01)
Estrogen involvement in breast cancer has been established; however, the association between breast cancer and thyroid diseases is controversial. Estrogen-like effects of thyroid hormone on breast cancer cell growth in ...
2D QSAR studies on thyroid hormone receptor ligands
(2007)
2D QSAR studies were carried out for a series of 55 ligands for the Thyroid receptors, TRα and TRβ. Significant cross-validated correlation coefficients (q2 = 0.781 (TRα) and 0.693 (TRβ)) were obtained. The models’ predictive ...
Fitoligantes derivados de plantas medicinais e ativa????o do receptor do horm??nio tireoidiano
(Instituto de LetrasPrograma de P??s-Gradua????o em Letras e Ling????sticaUFBAbrasil, 2019-02-21)