Buscar
Mostrando ítems 31-40 de 861
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates
(2016)
Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...
MicroRNoma do carcinoma de pâncreas
(Universidade Estadual Paulista (Unesp), 2016-01-22)
Background: Genetic alterations were previously identified and associated with the development and progression of pancreatic carcinoma, however, identification of such alterations has not been currently used for the ...
Daily rhythms in locomotor circuits in Drosophila involve PDF
(American Physiological Society, 2013-05)
The neuropeptide pigment-dispersing factor (PDF) has been studied extensively in Drosophila, and its role in circadian time-keeping has been firmly established. The role of PDF outside of the clock circuit, however, is ...
MicroRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma
(2019-05-01)
Despite progress in treatment strategies, only ~24% of pancreatic ductal adenocarcinoma (PDAC) patients survive >1 year. Our goal was to elucidate deregulated pathways modulated by microRNAs (miRNAs) in PDAC and Vater ...
Mecanismos genômicos e não-genômicos de controle da sinalização do AMP cíclico
(Universidade Federal de São Paulo (UNIFESP), 2009-07-29)
cyclic AMP (cAMP)-mediated pathway regulates several aspects of muscle and neuromuscular synapse physiology such as anabolism, neurotransmitter release and expression and function of crucial synaptic proteins like ...
Expression Profile of Rat Hippocampal Neurons Treated with the Neuroprotective Compound 2,4-Dinitrophenol: Up-Regulation of cAMP Signaling Genes
(SPRINGER, 2010)
2,4-Dinitrophenol (DNP) is classically known as a mitochondrial uncoupler and, at high concentrations, is toxic to a variety of cells. However, it has recently been shown that, at subtoxic concentrations, DNP protects ...
"Desenvolvimento e progressão de tumores da mama: onde o Ca2+ se encontra com o AMPc."
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2021-12-09)
With great epidemiological importance worldwide, breast cancer is considered the most common and the one with the highest mortality among women. Important for control of intracellular Ca2+ concentration and already used ...