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Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3
(Elsevier, 2018)
Abstract: Background and aims—Recent in vitro studies have showed that in macrophages deletion of
the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein
BMP-2. The pathophysiological ...
Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation
(National Academy of Sciences, 2016-02)
Lipid oxidation products, including lysophosphatidylcholine (lysoPC), activate canonical transient receptor potential 6 (TRPC6) channels leading to inhibition of endothelial cell (EC) migration in vitro and delayed EC ...
Ca2+ entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex
(Company of Biologists, 2019)
Abstract: Properties of adipocytes, including differentiation and adipokine secretion, are crucial factors in obesity-associated metabolic syndrome. Here, we provide evidence that Ca2+ influx in primary adipocytes, especially ...
Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells
(Wiley, 2017)
Abstract: Depletion of Ca2+ stores activates store-operated channels (SOCs), which mediate Ca2+ entry pathways that regulate cellular processes such as contraction, proliferation and gene expression. In vascular smooth ...
Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli
(Nature Publishing Group, 2014-09)
A key role for podocytes in the pathogenesis of proteinuric renal diseases has been established. Angiotensin II causes depolarization and increased intracellular calcium concentration in podocytes; members of the cation ...
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway
(e-Century Publishing, 2017)
Abstract: TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitial damage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy ...
TRPC1 regulates calcium-activated chloride channels in salivary gland cells
(Wiley-liss, Div John Wiley & Sons Inc, 2015-11)
Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion. It has been suggested that in salivary tissues, sustained fluid secretion is dependent on Ca2+ influx that activates ion ...
Lipid-independent control of endothelial and neuronal TRPC3 channels by light
(Royal Society of Chemistry, 2019-01)
Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting precise pharmacological control over their activity in native cells is expected to serve as a basis for the development of ...
TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
(Wiley, 2019)
Abstract: Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short-lasting form of memory involves sustained ("persistent") neuronal firing which may be ...
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke
(Lausanne: Frontiers Media, 2021)
Abstract: The seven canonical members of transient receptor potential (TRPC) proteins
form cation channels that evoke membrane depolarization and intracellular calcium
concentration ([Ca2C]i) rise, which are not only ...