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Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
(Public Library Science, 2017)
Adoptive transfer of CD4+CD25+FOXP3+ regulatory T cells (Treg cells) has been successfully
utilized to treat graft versus host disease and represents a promising strategy for the
treatment of autoimmune diseases and ...
Aumento de linfocitos T regulatorios en los ganglios linfoides de ratones mutantes para catepsina LIncrease of regulatory T cells in the lymph node of cathepsin L mutant mice
(Medicina (Buenos Aires), 2011-04)
Las células T regulatorias CD4+CD25+Foxp3+ (Treg) han sido implicadas en el rechazo al trasplante de órganos alogeneicos, en cáncer, infecciones y enfermedades autoinmunes. Así, su modulación posee un enorme potencial para ...
Regulatory T cell phenotype and anti osteoclastogenic function in experimental periodontitis
(Nature, 2020)
The alveolar bone resorption is a distinctive feature of periodontitis progression and determinant for tooth loss. Regulatory T lymphocytes (Tregs) display immuno-suppressive mechanisms and tissue repairing functions, which ...
Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection
(Wiley-Blackwell, 2015)
CD4+CD25+Foxp3+ regulatory T (Treg) cells mediate immunological self-tolerance and
suppress immune responses. Retinoic acid (RA), a natural metabolite of vitamin A, has
been reported to enhance the differentiation of ...
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction
(2018-10-01)
Background/Aims: The objective of our study was to evaluate the effects of zinc supplementation on cardiac remodeling following acute myocardial infarction in rats. Methods: Animals were subdivided into 4 groups and observed ...
Células T reguladoras em sangue periférico de cães portadores de mastocitoma cutâneo
(Universidade Estadual Paulista (Unesp), 2014-07-11)
Mast cell tumor is a neoplastic proliferation of mast cells which is the most frequent cutaneous tumor in dogs. Its extremely variable biological behavior makes the prognostic and therapeutic determination more difficult, ...
Dendritic Cells and B Cells Cooperate in the Generation of CD4+ CD25+ FOXP3+ Allogeneic T Cells
(ELSEVIER, 2010)
Background. CD4 CD25 Foxp3 regulatory T cells (Treg) play an essential role in
immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an
important role in maintaining immunosuppression ...
Inducción de tolerancia periférica en trasplantes alogénicos
(Universidad Andrés Bello, 2010)
La regulación inmune o inmunosupresión desempeña un papel trascendental en trasplante de órganos donde los linfocitos T reguladores (Tregs) son piezas claves de la compleja estructura de la respuesta inmune. Los linfocitos ...