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Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease
(2018)
Alzheimer's disease (AD) is characterized by progressive memory loss and dementia. The strong correlation between cognitive decline and the loss of synapses supports the idea that synaptic damage is a relevant pathogenic ...
Mitochondrial dysfunction associated with nitric oxide pathways in glutamate neurotoxicityDisfunción mitocondrial asociada a las vías del óxido nítrico en la neurotoxicidad por glutamato
(Elsevier Doyma Sl, 2017-03)
Recientemente se han evaluado múltiples mecanismos que subyacen a la neurotoxicidad inducida por el glutamato. En este sentido, pacientes con neurodegeneración presentan disfunción mitocondrial, estrés oxidativo e inflamación. ...
The nitric oxide pathways in the neurotoxicity from glutamate-induced apoptosis
(Springer, 2017)
Glutamate is a key neurotransmitter in the central nervous system; however, excessive levels may produce neurotoxicity as well as the neurodegenerative diseases development. In the last time, multiples mechanisms underlying ...
Investigação dos imunomoduladores produzidos por astrócitos derivados de células-tronco de pluripotência induzida (hIPSCs) de pacientes com esquizofrenia
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2018-02-21)
Schizophrenia is a psychiatric disorder, caused by a conjunction of genetic,
environmental and developmental factors. Individuals bearing this disease exhibit
cognitive deficits, positive (psychosis, hallucinations and ...
Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic-purinergic block
(ELSEVIER SCIENCE BV, 2007)
Acetylcholine (ACh) and ATP have been proposed as excitatory co-transmitters operating at synapses between glomus cells and sensory nerve endings of the carotid body (CB). To test such hypothesis, we performed experiments ...