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The mean corpuscular volume and hydroxyurea in brazilian patients with sickle cell anemia: a surrogate marker of compliance
(2013)
The suppression of erythropoiesis by Hydroxyurea (HU) therapy is associated with increase in mean corpuscular volume, in addition to the increase in Hb F. Monitoring the mean corpuscular volume values and the presence of ...
Fatores moduladores da gravidade da evolução clínica da anemia falciforme
(Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2007-09-01)
Sickle cell anemia is a heterogeneous disorder with different degrees of clinical severity despite of being caused by a single base pair mutation (Glu6Val) of the ß-globin gene. Understanding this disease will allow us to ...
Effects of hydroxyurea in a population of Brazilian patients with sickle cell anemia
(Wiley-Blackwell, 2005-03-01)
Fetal hemoglobin (HbF) inhibits the polymerization of sickle hemoglobin, modulating the clinical features of sickle cell anemia (SCA). Hydroxyurea (HU) therapy can increase the HbF level, although its production can be ...
Clinical, hematological, and molecular characterization of sickle cell anemia pediatric patients from two different cities in Brazil
(Cadernos de Sa??de P??blica, 2005)