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Sphingolipids as emerging mediators in retina degeneration
(Frontiers Media S.A., 2019-06-11)
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions. Their roles in the retina have gained ...
Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome
(Oxford University Press, 2016-12-07)
re follicular fluid (FF) sphingosine-1-phosphate (S1P) levels in patients at risk of developing ovarian hyperstimulation syndrome (OHSS) altered and in part responsible for the high vascular permeability observed in these ...
Inositolphosphoceramide metabolism in Trypanosoma cruzi as compared with other trypanosomatids
(Wiley Blackwell Publishing, Inc, 2011-03)
Chagas disease is caused by Trypanosoma cruzi and is endemic to North, Central and South American countries. Current therapy against this disease is only partially effective and produces adverse side effects. Studies on ...
Alteration of sphingolipids in biofluids: Implications for neurodegenerative Diseases
(Multidisciplinary Digital Publishing Institute, 2019-07-21)
Sphingolipids (SL) modulate several cellular processes including cell death, proliferation and autophagy. The conversion of sphingomyelin (SM) to ceramide and the balance between ceramide and sphingosine-1-phosphate (S1P), ...
El Ca2+ y los esfingolípidos como moduladores de la apoptosis y el cáncer.
(Investigación Clínica, 2017)
Decreased caveolae in AGPAT2 lacking adipocytes is independent of changes in cholesterol or sphingolipid levels: A whole cell and plasma membrane lipidomic analysis of adipogenesis
(2021)
Background
Adipocytes from lipodystrophic Agpat2−/− mice have impaired adipogenesis and fewer caveolae. Herein, we examined whether these defects are associated with changes in lipid composition or abnormal levels of ...
Biochemical characterization of serine transport in Leishmania (Leishmania) amazonensis
(ELSEVIER SCIENCE BV, 2009)
In addition to its role as a protein component in Leishmania, serine is also a precursor for the synthesis of both phosphatidylserine, which is a membrane molecule involved in parasite invasion and inactivation of macrophages, ...
Transbilayer asymmetry and sphingomyelin composition modulate the preferential membrane partitioning of the nicotinic acetylcholine receptor in Lo domains
(Elsevier Science Inc, 2015-12)
We have previously shown that the intact nicotinic acetylcholine receptor (AChR) lacks preference for Lo domains when reconstituted in a sphingomyelin (SM), cholesterol (Chol) and POPC (1:1:1) model system (Bermúdez V, ...