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Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer
(Oncotarget, 2015-08-28)
Monocarboxylate Transporter 2 (MCT2) is a major pyruvate transporter encoded by the SLC16A7 gene. Recent studies pointed to a consistent overexpression of MCT2 in prostate cancer (PCa) suggesting MCT2 as a putative biomarker ...
Insulin-Stimulated L-Arginine Transport Requires SLC7A1 Gene Expression and Is Associated With Human Umbilical Vein Relaxation
(WILEY, 2011)
Insulin causes endothelium-derived nitric oxide (NO)-dependent vascular relaxation, and increases L-arginine transport via cationic amino acid transporter 1 (hCAT-1) and endothelialNOsynthase (eNOS) expression and activity ...
D-Glucose increases the expression and activity of hCAT-1 and Spl binding to SLC7A1 promoter in human umbilical vein endothelium
(2008)
L-Arginine is mainly transported by the human cationic amino acid transporter 1 (hCAT-1, protein codified by the gene SLC7A1) in human umbilical vein endothelial cells (HUVEC). hCAT-1 mediated L-arginine transport and ...
Caracterización de las proteínas de membrana implicadas en el metabolismo del yodo NIS y SLC5A8
(2009)
La proteína NIS cataliza el transporte activo de yodo hacia el interior de los folículos tiroideos. En este trabajo se estudió la rapidez y reversibilidad de la inhibición catalizada 10 moléculas (posibles inhibidores de ...
Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population
(SBEM-Soc Brasil Endocrinologia & Metabologia, 2021)
Objective: To study the association of SLC16A11 gene variants with obesity and metabolic markers
in nondiabetic Chilean adults. Materials and methods: This cross-sectional study included 263 nondiabetic
adults. The ...
SLC2A9 Is a High-Capacity Urate Transporter in Humans
(PUBLIC LIBRARY SCIENCE, 2008)
Background
A compound heterozygote SLC26A2 mutation resulting in robin sequence, mild limbs shortness, accelerated carpal ossification, and multiple epiphysial dysplasia in two Brazilian sisters. A new intermediate phenotype between diastrophic dysplasia and recessive multiple epiphyseal dysplasia
(John Wiley & SonsHoboken, 2013-08)
Mutations in solute carrier family 26 (sulfate transporter), member 2 (SLC26A2) gene result in a spectrum of autosomal recessive chondrodysplasias that range from the mildest recessive form of multiple epiphysial dysplasia ...
Inhibition of the sodium-dependent HCO3 - transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype
(2022-05)
Bicarbonate secretion is a fundamental process involved in maintaining acid-base homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in lung ...
Interference of age and supplementation of direct-fed microbial and essential oil in the activity of digestive enzymes and expression of genes related to transport and digestion of carbohydrates and proteins in the small intestine of broilers
(2017-08-01)
The objectives of this study were to describe alterations that age and dietary inclusion of direct-fed microbial (DFM) Bacillus subtilis (BS) and a specific essential oil (EO) blend (carvacrol, cinnamaldehyde, cineol, and ...