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Impaired replication of hepatitis C virus containing mutations in a conserved NS5B retinoblastoma protein-binding motif
(2009)
Hepatitis C virus (HCV) downregulates the retinoblastoma tumor suppressor protein (Rb), a central cell cycle regulator which is also targeted by oncoproteins expressed by DNA tumor viruses. HCV genome replication is also ...
Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos
(Elsevier Inc, 2010-05-01)
Mouse oocytes acquire the ability to replicate DNA during meiotic maturation, presumably to ensure that DNA replication does not occur precociously between MI and MII and only after fertilization. Acquisition of DNA ...
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
(2008)
The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell survival under endoplasmic reticulum (ER) stress conditions. X-box-binding protein-1 (XBP-1) is a key transcriptional regulator of ...
Discovery of a new antiviral protein isolated Lonomia obliqua analysed by bioinformatics and real-time approaches
(2014)
This study presents a new recombinant protein that acts as a powerful antiviral (rAVLO—recombinant Antiviral protein of Lonomia obliqua). It was able to reduce the replication by 106 fold for herpes virus and by 104 fold ...
Structure, function and evolution of the animal mitochondrial replicative DNA helicase
(Taylor & Francis Ltd, 2016-01-02)
The mitochondrial replicative DNA helicase is essential for animal mitochondrial DNA (mtDNA) maintenance. Deleterious mutations in the gene that encodes it cause mitochondrial dysfunction manifested in developmental delays, ...
Exploring RNA Virus Replication in Xenopus Oocytes
(Humana Press, 2006)
Microinjection of poliovirus RNA in Xenopus oocytes initiates a complete and authentic viral replication cycle that yields newly synthesized infectious virus. This system can be used to study the molecular mechanism of the ...
Replication Protein A-1 Has a Preference for the Telomeric G-rich Sequence in Trypanosoma cruzi
(2018-05-01)
Replication protein A (RPA), the major eukaryotic single-stranded binding protein, is a heterotrimeric complex formed by RPA-1, RPA-2, and RPA-3. RPA is a fundamental player in replication, repair, recombination, and ...