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Molecular adjuvants that modulate regulatory T cell function in vaccination: A critical appraisal
(2018-03-01)
Adjuvants are substances used to enhance the efficacy of vaccines. They influence the magnitude and alter the quality of the adaptive immune response to vaccine antigens by amplifying or modulating different signals involved ...
Regulatory T cells and vaccine effectiveness in older adults. Challenges and prospects
(2021-07-01)
Since the discovery of lymphocytes with immunosuppressive activity, increasing interest has arisen in their possible influence on the immune response induced by vaccines. Regulatory T cells (Tregs) are essential for ...
Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 immune response in murine sporotrichosis caused by Sporothrix schenckii
(2020-09-01)
The role of regulatory T cells (Tregs) on protective immunity in fungal infections, is controversial. Sporotrichosis is an emerging and worldwide-distributed subcutaneous mycosis caused by various related thermodimorphic ...
Limited Foxp3+ regulatory T cells response during acute Trypanosoma cruzi infection is required to allow the emergence of robust parasite-specific CD8+ T cell immunity
(Frontiers Media S.A., 2018-11)
While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg ...
Regulatory T cells and IgE expression in duodenal mucosa of Strongyloides stercoralis and human T lymphotropic virus type 1 co-infected patients
(Public Library of Science, 2019)
BACKGROUND: Strongyloides stercoralis is an intestinal nematode unique in its ability to replicate in the human host, allowing ongoing cycles of autoinfection, persisting for decades within the same host. Although usually ...
Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
(2006)
CBA/J mice are resistant to Leishmania major and susceptible to Leishmania amazonensis. Early events determine infection outcome. Until now, PIV (in vitro priming) immune response to L. amazonensis has not been assessed. ...
Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3(+) regulatory T cells in skin-transplanted mice
(Wiley-Blackwell, 2015)
Interleukin-33 (IL-33) has been a focus of study because of its variety of
functions shaping CD4+ T-cell biology. In the present work, we evaluated
the modulatory effect of IL-33 on suppressor cells in an in vivo ...
Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
(American Society for Microbiology, 2008)
Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. Here, we show in a natural model of MMTV infection that the virus causes early ...
Expansion of CD4(+) CD25(+) Foxp3(+) T cells by bone marrow-derived dendritic cells
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Dendritic cells (DCs) are the most important antigen-presenting cells of the immune system and have a crucial role in T-lymphocyte activation and adaptive immunity initiation. However, DCs have also been implicated in ...
T regulatory cells-derived extracellular vesicles and their contribution to the generation of immune tolerance
(Wiley, 2020)
T regulatory (Treg) cells have a major role in the maintenance of immune tolerance against self and foreign antigens through the control of harmful inflammation. Treg cells exert immunosuppressive function by several ...