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Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis
(HindawiGrupo de Inmunología Celular e InmunogenéticaGrupo de Reumatología Universidad de Antioquia -GRUA-Nueva York, Estados Unidos, 2022)
Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Anti-IgE, omalizumab, inhibits the allergen response in patients with asthma. This has not been directly related to changes in inflammatory conditions. We hypothesized that anti-IgE exerts its effects by reducing airway ...
Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémico
(Sociedad Médica de Santiago, 2003)
Autoantibodies against muscarinic receptors in breast cancer. Its role in tumor angiogenesis.
(Public Library Science, 2013-02)
The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells. Immunoglobulin G (IgG) from breast cancer patients in T1N0Mx stage (tumor size¡Ü2 cm, without lymph node metastasis) mimics the action of the muscarinic agonist carbachol stimulating MCF-7 cell proliferation, migration and invasion. Angiogenesis is a central step in tumor progression because it promotes tumor invasion and metastatic spread. Vascular endothelial growth factor-A (VEGF-A) is the main angiogenic mediator, and its levels have been correlated with poor prognosis in cancer. The aim of the present work was to investigate the effect of T1N0Mx-IgG on the expression of VEGF-A, and the in vivo neovascular response triggered by MCF-7 cells, via muscarinic receptor activation. We demonstrated that T1N0Mx-IgG (10<sup><font size="2">−8</font></sup> M) and carbachol (10<sup><font size="2">−9</font></sup> M) increased the constitutive expression of VEGF-A in tumor cells, effect that was reverted by the muscarinic antagonist atropine. We also observed that T1N0Mx-IgG and carbachol enhanced the neovascular response produced by MCF-7 cells in the skin of NUDE mice. The action of IgG or carbachol was reduced in the presence of atropine. In conclusion, T1N0Mx-IgG and carbachol may promote VEGF-A production and neovascularization induced by breast tumor cells via muscarinic receptors activation. These effects may be accelerating breast tumor progression....
Fcγ Receptor IIa (FCGR2A) Polymorphism Is Associated With Severe Respiratory Syncytial Virus Disease in Argentinian Infants
(Frontiers Media, 2020-12)
Background: Most patients with respiratory syncytial virus (RSV) infection requiring hospitalization have no risk factors for severe disease. Genetic variation in the receptor for the Fc portion of IgG (FcγR) determines ...
Autoantibodies against Muscarinic Acetylcholine Receptor on Exocrine Glands in Sjögren Syndrome
(OMICS International, 2014-12)
These investigations demonstrate that serum antibodies against muscarinic acetylcholine receptors (mAChR) in primary Sjögren syndrome (pSS) and associated Sjögren syndrome (aSS) bind and activate both cholinergic receptors ...
CD 64 como possível alvo terapéutico na Leishmaniose humana
(Sociedade Brasileira de Medicina Tropical, 2020)
Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China,
at the end of 2019, and there are currently no specific antiviral treatments or vaccines
available. SARS-CoV-2 has been shown to use ...