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Distinct binding mode of I-125-AngII to AT(1) receptor without the Cys(18)-Cys(274) disulfide bridge
(Elsevier B.V., 2009-11-27)
Previous studies on angiotensin II (AngII) AT(1) receptor function have revealed that the N-terminal residues of AngII may modulate receptor activation by binding at the receptor extracellular site. A remarkable feature ...
Expression and functional role of α7 nicotinic receptor in human cytokine-stimulated natural killer (NK) cells
(American Society for Biochemistry and Molecular Biology, 2016-06-09)
The homomeric α7 nicotinic receptor (nAChR) is one of the most abundant nAChRs in the central nervous system where it contributes to cognition, attention, and working memory. α7 nAChR is also present in lymphocytes, dendritic ...
Molecular modulation of human α7 nicotinic receptor by amyloid-β peptides
(Frontiers Media S.A., 2019-02-08)
Amyloid β peptide (Aβ) is a key player in the development of Alzheimer’s disease (AD). It is the primary component of senile plaques in AD patients and is also found in soluble forms. Cholinergic activity mediated by α7 ...