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Facilitation of 5-HT(2A/2C)-mediated neurotransmission in the ventromedial hypothalamic nucleus decreases anxiety in the elevated T-maze
(ELSEVIER SCIENCE BV, 2011)
Previous evidence has shown that facilitation of GABA/benzodiazepine-mediated neurotransmission in the ventromedial hypothalamus (VMH) inhibits both escape and inhibitory avoidance responses generated in the elevated T-maze ...
Avaliação do papel dos receptores 5-HT3 da substância cinzenta periaquedutal de camundongos submetidos ao labirinto em cruz elevado
(Universidade Federal de São CarlosBRUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF, 2009-04-24)
The exposure of animals to aversive situations, such as elevated plus-maze (EPM), activates serotonergic pathways with projections into structures involved in the defense system, such as the amygdala, septum, hypothalamus, ...
ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist
(Elsevier Science Inc., 2000-06-06)
To assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged
anxiolytic and hallucinogenic properties, Xenopus laevis oocytes were microinjected with either
of the rat cRNA for the ...
5-HT2C receptor regulation of defensive responses in the rat dorsal periaqueductal gray
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Activation of 5-HT2C receptors in limbic structures such as the amygdala and hippocampus increases anxiety. Indirect evidence obtained with non-selective 5-HT2C-interacting drugs suggests that the same may occur in the ...
5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice
(Elsevier B.V., 2008-02-11)
It is widely acknowledged that the indoleamine neurotransmitter serotonin (5-HT) plays a dual role in the regulation of anxiety, a role that in part depends upon neuroanatomical locus of action. Thus, whereas stimulation ...
5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice
(Elsevier B.V., 2008-02-11)
It is widely acknowledged that the indoleamine neurotransmitter serotonin (5-HT) plays a dual role in the regulation of anxiety, a role that in part depends upon neuroanatomical locus of action. Thus, whereas stimulation ...
Human 5-HT3 receptors: Structural and functional features
(Sociedad Argentina de Investigación en Neurociencias, 2020)
The 5-HT3 receptor is a ligand-gated ion channel that converts the binding of serotonin (5-HT) into a transient cation current which mediates fast excitatory responses in peripheral and central nervous systems. Five human ...