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Staphylococcus aureus alpha-toxin induces the formation of dynamic tubules labeled with LC3 within host cells in a Rab7 and rab1b-dependent manner
(Frontiers Research Foundation, 2017-10)
Staphylococcus aureus is a pathogen that causes severe infectious diseases that eventually lead to septic and toxic shock. S. aureus infection is characterized by the production of virulence factors, including enzymes and ...
Via secretoria de proteinas : estudio de la actividad reguladora de la gtpasa rab1b
(2009)
transporte intracelular de proteínas es una actividad esencial para las células eucariotas. Mediante este proceso se llevan a cabo numerosas actividades importantes para la viabilidad celular y para la integración de la ...
TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3K gamma for Suppression of Inflammatory Responses
(2018)
The multi-ligand endocytic receptor, low-density lipoprotein-receptor-related protein 1 (LRP1), has anti-inflammatory roles in disease. Here, we reveal that pathogen-activated Toll-like receptors (TLRs) activate LRP1 in ...
Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate
(Rockefeller University Press, 2015-02)
During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55Gag is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. ...
Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated with loss of cell polarity and secretory dysfunction
(2011)
Objective Oral and ocular dryness are frequent and serious symptoms of Sjögren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
Rab35 roles in actin dynamics and axon elongation are negatively regulated by PRPK
(2015)
is a crucial process through which neuronal final shape is achieved, and a mechanism
sustained mainly by cytoskeletal dynamics and intracellular trafficking. We previously
described that microtubule-associated protein 1B ...
Rab35-dependent axon elongation is negatively regulated by p53-related protein kinase (PRPK)
(2014)
The appropriate function of the nervous system relies on the neuronal polarized morphology. Axon
elongation is a crucial process through neuronal final shape is achieved, and a mechanism sustained
mainly by cytoskeletal ...