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Altered Renal Expression of Relevant Clinical Drug Transporters in Different Models of Acute Uremia in Rats. Role of Urea Levels
(Karger, 2015-07)
Background/Aims: Organic anion transporter 1 (Oat1) and 3 (Oat3) are organic anion transporters that play critical roles in the body disposition of numerous clinically important drugs. We investigated the effects of acute ...
Organic anion transporter 5 renal expression and urinary excretion in rats with vascular calcification
(Hindawi Publishing Corporation, 2013-10)
It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. ...
Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions
(Wiley Blackwell Publishing, Inc, 2017-08)
Aim: Furosemide is a loop diuretic. Different authors demonstrated that continuous administration of furosemide modulates the expression of organic anion transporters. This study was undertaken to simultaneously evaluate ...
Avaliação do impacto tardio da lesão renal aguda induzida por isquemia reperfusão no transporte de Na+ dependente de ATP do túbulo proximal
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Bioquimica e Fisiologia, 2020)
Effect of long-term type 1 diabetes on renal sodium and water transporters in rats
(Karger, 2008-01-01)
The effects of long-term diabetes in the presence of established nephropathy on tubular function remains poorly understood. We evaluated the levels of the main sodium and water transport proteins expressed in the kidney ...
Organic anion transporter 5 (Oat5) renal expression and urinary excretion in rats treated with cisplatin: a potential biomarker of cisplatin-induced nephrotoxicity
(Springer, 2013-05)
Cisplatin is one of the most potent chemotherapeutic antitumor drugs used in the treatment of a wide range of solid tumors. Its primary dose-limiting side effect is nephrotoxicity. The organic anion transporter 5 (Oat5) ...