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Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics
(Elsevier Science Inc, 2018-04)
Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance ...
RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis
(Elsevier Science, 2007-10)
The nuclear receptor coactivator RAC3 plays important roles in many biological processes and tumorigenesis. We found that RAC3 is over-expressed in human chronic myeloid leukemia cells K562, which are normally resistant ...
Interação entre IQGAP1 e actina mediado por CDC42 e RAC1
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação em Genética e BioquímicaCiências BiológicasUFU, 2016)
Ractopamina y nivel de proteína de la dieta, respuesta productiva y características de la carcasa de cuyes (Cavia porcellus)
(Universidad Nacional Agraria La Molina, 2017)
El objetivo del presente trabajo fue determinar el efecto del Clorhidrato de Ractopamina (RAC) y el nivel de proteína de la dieta sobre la respuesta productiva y características de la carcasa de cuyes (Cavia porcellus). ...
FMNL1 promotes proliferation and migration of leukemia cells
(Federation Amer Soc Exp BiolBethesdaEUA, 2013)
Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines
(Bentham Science Publishers, 2013-09)
Rho GTPases play a key role in the regulation of multiple essential cellular processes, including actin dynamics, gene transcription and cell cycle progression. Aberrant activation of Rac1, a member of Rho family of small ...
Spatiotemporal analysis of RhoA and Rac1 activation for cell polarization
(2017)
Introduction: The Rho-family of GTPases are critical in regulating cytoskeletal rearrangements during cell migration. It have been described that Rac1 is involved in lamellipodia formation and RhoA in cell contractility ...