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Photooxidation of Tryptophan and Tyrosine Residues in Human Serum Albumin Sensitized by Pterin: A Model for Globular Protein Photodamage in Skin
(American Chemical Society, 2016-08)
Human serum albumin (HSA) is the most abundant protein in the circulatory system. Oxidized albumin was identified in the skin of patients suffering from vitiligo, a depigmentation disorder in which the protection against ...
Tryptophan Oxidation Photosensitizided by Pterin
(Elsevier, 2013-05)
Pterins are normal components of cells and they have been previously identified as good photosensitizers under UV-A irradiation, inducing DNA damage and oxidation of nucleotides. In this work, we have investigated the ...
Photosensitization of bovine serum albumin by pterin: a mechanistic study
(Elsevier, 2013-03)
Pterins, heterocyclic compounds widespread in biological systems, are able to photoinduce oxidation of DNA and its components. In the present study, we have investigated the photosensitizing properties of pterin (Ptr), the ...
Quenching of the Singlet and Triplet Excited States of Pterin by Amino Acids
(Wiley Blackwell Publishing, Inc, 2019-01)
Unconjugated oxidized pterins accumulate in the skin of patients suffering from vitiligo and, under UVA irradiation, photosensitize the oxidation of amino acids. In this work, we study the interaction of the singlet and ...
Photophysics, photochemistry and thermally-induced redox reactions of a (Pterin)rhenium(I) complex
(Elsevier Science Sa, 2018-05)
In this work, we present a whole and deep study on the thermal redox and the photophysical and photochemical reactions of a tricarbonyl Re(I) complex coordinating Pterin, fac-ReI(CO)3(pterin)(H2O) (pterin = 2-amino-4-oxo ...
Unraveling the degradation mechanism of purine nucleotides photosensitized by pterins: the role of charge-transfer steps
(Royal Society Of Chemistry, 2015-04)
Photosensitized reactions contribute to the generation of skin cancer and are used in many applications. The photosensitizers may act through different mechanisms. It is currently accepted that if the photosensitizer ...
A novel synthetic approach to tyrosine dimers based on pterin photosensitization
(Elsevier, 2017-12)
Oxidative damage to proteins leads to a variety of modifications that are markers of pathogenesis. One of the most important modifications is the dityrosine (Tyr2) cross-link, resulting from an oxidative covalent bond ...
Continuum, Discrete, and Explicit Solvation Models for Describing the Low-Lying Absorption Spectrum of the Pterin Acid in Aqueous Environment
(JOHN WILEY & SONS INC, 2010)
The absorption spectrum of the acid form of pterin in water was investigated theoretically. Different procedures using continuum, discrete, and explicit models were used to include the solvation effect on the absorption ...
Oxidation of biomolecules photosensitized by pterin derivatives
(Asociación Química Argentina, 2020-12)
La importancia biológica y médica de las reacciones fotosensibilizadas se relaciona principalmente con su participación en los procesos involucrados en el desarrollo de cáncer de piel y de terapias fotodinámicas para el ...