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In silico identification of conserved intercoding sequences in Leishmania genomes: unraveling putative cis-regulatory elements.
(Elsevier/North-Holland Biomedical Press, 2014)
Genome-Scale Protein Microarray Comparison of Human Antibody Responses in Plasmodium vivax Relapse and Reinfection
(American Society of Tropical Medicine and Hygiene, 2015)
Large scale antibody responses in Plasmodium vivax malaria remains unexplored in the endemic setting. Protein microarray analysis of asexual-stage P. vivax was used to identify antigens recognized in sera from residents ...
Rapid, selection-free, high-efficiency genome editing in protozoan parasites using CRISPR-cas9 ribonucleoproteins
(American Society for Microbiology, 2017-11-07)
Trypanosomatids (order Kinetoplastida), including the human pathogens Trypanosoma cruzi (agent of Chagas disease), Trypanosoma brucei, (African sleeping sickness), and Leishmania (leishmaniasis), affect millions of people ...
DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide
(American Society for Microbiology, 2001-04)
The activation of innate immune responses by genomic DNA from bacteria and several nonvertebrate organisms represents a novel mechanism of pathogen recognition. We recently demonstrated the CpG-dependent mitogenic activity ...
Comparative genomics, phylogenomics and population genomics of New World Leishmania
(Universidade Federal de Minas GeraisUFMG, 2016-03-31)
Leishmaniasis is a complex parasitic disease with diverse clinical manifestations and epidemiology that is caused by protozoan belonging to the genus Leishmania. These parasites are transmitted to the mammalian host by the ...
Use of LeishGEdit CRISPR-Cas9 technology for genetic manipulation of protozoan parasite Leishmania
(JoVE, 2021)
The cell biology of a parasitic protozoan as well as the impact of the infection in host cells can be addressed using genome modification techniques. The development of robust methods eases the burden to obtain gene mutants ...
Evidence for repeated gene duplications in Tritrichomonas foetus supported by EST analysis and comparison with the Trichomonas vaginalis genome
(Elsevier Science, 2014-12)
Tritrichomonas foetus causes a venereal infection in cattle; the disease has mild or no clinical manifestation in bulls, while cows may present vaginitis, placentitis, pyometra and abortion in the more severe cases. T. ...