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Organ-on-a-Chip systems for new drugs development
(2021-03-22)
Research on alternatives to the use of animal models and cell cultures has led to the creation of organ-ona-chip systems, in which organs and their physiological reactions to the presence of external stimuli are
simulated. ...
Transcatheter mitral valve replacement with the NaviGate stent in a preclinical model
(Europa Edition, 2017)
Aims: The aim of this study was to test the feasibility of transcatheter mitral valve implantation of the NaviGate device in acute and chronic preclinical models.
Methods and results: We evaluated NaviGate valved stent ...
Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus
(Mdpi, 2019-11-01)
Background: The presence of beta-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were ...
Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats
(2019-11)
The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However,
CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents,
despite the evidence ...
Immunotherapies for brain cancer: from preclinical models to human trials
(Springer, 2014)
Glioblastoma Multiforme (GBM) is the most common and aggressive primary brain tumor. Every year ~22,000 patients are diagnosed with GBM in the US, and less than 5% survive 5 years post-diagnosis. Thus, novel therapeutic ...
Lamotrigine as a mood stabilizer: insights from the pre-clinical evidence
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MORFOLOGIAICX - DEPARTAMENTO DE QUÍMICAMED - DEPARTAMENTO DE CLÍNICA MÉDICAUFMG, 2019)
Mesenchymal stem cell therapy promotes the improvement and recovery of renal function in a preclinical model
(Soc Brasil Genetica, 2016-04-01)
Acute renal failure (ARF) is an extremely important public health issue in need of novel therapies. The present study aimed to evaluate the capacity of mesenchymal stem cell (MSC) therapy to promote the improvement and ...