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Action of flavonoids on conversion of long chain polyunsaturated fatty acids from essential fatty acids Acción de flavonoides sobre la conversión de ácidos grasos poliinsaturados de cadena larga a partir de ácidos grasos esenciales
(Sociedad Chilena de Nutricion Bromatologia y Toxilogica, 2018)
© 2018, Sociedad Chilena de Nutricion Bromatologia y Toxilogica. All rights reserved. Epidemiological and clinical studies have reported multiple benefits from the intake of Long Chain Polyunsaturated Fatty Acids n-3 ...
Efecto de la suplementación con ácido docosahexaenoico más hidroxitirosol sobre la activación de PPARα y Nrf2 en la reducción de hígado graso no alcohólico inducido por dieta alta en grasa en ratón
(Universidad de Chile, 2017)
Introducción: La enfermedad por hígado graso no alcohólico se caracteriza por una
acumulación excesiva y patológica de grasa en los hepatocitos, asociándose con diversas
enfermedades crónicas de origen nutricional. Uno ...
Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease
(Elsevier, 2017-12)
Trypanosoma cruzi induces serious cardiac alterations during the chronic infection. Intense inflammatory response observed from the beginning of infection, is critical for the control of parasite proliferation and evolution ...
N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: Anti-inflammatory implications in liver ischemia-reperfusion injury
(2011)
Dietary supplementation with the n-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to rats preconditions the liver against ischemia-reperfusion (IR) injury, with reduction ...
Planejamento, síntese e avaliação farmacológica de novos compostos híbridos derivados de resveratrol e bezafibrato úteis ao tratamento da dislipidemia
(Universidade Estadual Paulista (Unesp), 2017-12-20)
A dislipidemia causada por hipertrigliceridemia e baixo HDL-C é um marcador de risco para a progressão da aterosclerose e doenças cardiovasculares. Os receptores PPARs são fatores de transcrição que controlam a expressão ...
PPAR alpha Agonists Reduce Alcohol Drinking: Do They Act in the Brain or in the Liver?
(2015)
There are good news for the alcohol field. In the past few years, peroxisome proliferator-activator drugs were reported to reduce voluntary alcohol intake in animal models. Barson et al. (2009) showed that gemfibrozil ...
Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice
(Elsevier Science, 2014-12)
Trypanosoma cruzi, the etiological agent of Chagas' disease, induces a persistent inflammatory response. Macrophages are a first line cell phenotype involved in the clearance of infection. Upon parasite uptake, these cells ...
Oleoylethanolamide and Palmitoylethanolamide Protect Cultured Cortical Neurons Against Hypoxia
(Mary Ann Liebert, 2018-09)
Introduction: Perinatal hypoxic-ischemic (HI) encephalopathy is defined as a neurological syndrome where the newborn suffers from acute ischemia and hypoxia during the perinatal period. New therapies are needed. The ...
Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and improves glucose tolerance in diet-induced obese mice
(2022-03-01)
Peroxisome proliferator-activated receptors are promising therapeutic targets for metabolic diseases, including obesity, diabetes, and dyslipidemia. This study describes the design, synthesis and pharmacological evaluation ...
Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation
(Royal Society of Chemistry, 2017)
© 2017 The Royal Society of Chemistry.Scope: Non-alcoholic fatty liver disease (NAFLD) is a condition characterized by an increment in the liver fat content, with a concomitant reduction in the content of n-3-long chain ...