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Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with Chagas disease
(Public Library of Science, 2013-02)
Clinical symptoms of chronic Chagas disease occur in around 30% of the individuals infected with Trypanosoma cruzi and are characterized by heart inflammation and dysfunction. The pathogenesis of chronic chagasic cardiomyopathy ...
Granulocyte colony-stimulating factor partially repairs the damage provoked by Trypanosoma cruzi in murine myocardium
(Elsevier Ireland, 2013-04)
Background: The hallmark of Trypanosoma cruzi infection is cardiomyopathy that leads to end-stage heart failure. We investigated whether G-CSF, known to induce heart tissue repair by bone marrow stem cell mobilization,ameliorates ...
Identification of novel vaccine candidates for Chagas’ disease by immunization with sequential fractions of a trypomastigote cDNA expression library
(Elsevier, 2009-02)
The protozoan Trypanosoma cruzi is the etiological agent of Chagas´ disease, a major chronic infection in Latin America. Currently, there are neither effective drugs nor vaccines for the treatment or prevention of the ...
Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection
(Frontiers Media S.A., 2020-07)
Galectins are animal lectins with high affinity for β-galactosides that drive the immune response through several mechanisms. In particular, the role of galectin-8 (Gal-8) in inflammation remains controversial. To analyze ...
Trypanosoma cruzi infection induces the expression of CD40 in murine cardiomyocytes favoring CD40 ligation-dependent production of cardiopathogenic IL-6
(Springer, 2015-11)
The inflammatory response in the myocardium is an important aspect of the pathogenesis of Chagas heart disease raised by Trypanosoma cruzi. CD40, a transmembrane type I receptor belonging to the tumor necrosis factor ...
Efficacy of voriconazole in a murine model of acute Trypanosoma cruzi infection
(Oxford University Press, 2012-12)
OBJECTIVES: Antifungal triazole derivatives have been studied as possible alternatives for the treatment of Chagas' disease. Voriconazole has demonstrated in vitro activity against Trypanosoma cruzi, but its efficacy in ...
Trypanosoma cruzi infection in Cyclophilin D deficient mice
(Academic Press Inc Elsevier Science, 2021-01)
Trypanosoma cruzi is the causative agent of Chagas disease, which is endemic in Latin America and around the world through mother to child transmission. The heart is the organ most frequently affected in the chronic stage ...
Oxidative stress damage in the protozoan parasite Trypanosoma cruzi is inhibited by Cyclosporin A
(Cambridge University Press, 2015-07)
Cyclosporin A (CsA) specifically inhibits the mitochondrial permeability transition pore (mPTP). Opening of the mPTP, which is triggered by high levels of matrix [Ca2+] and/or oxidative stress, leads to mitochondrial ...