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Altered Oxygen Metabolism Associated to Neurogenesis of Induced Pluripotent Stem Cells Derived From a Schizophrenic Patient
(COGNIZANT COMMUNICATION CORPPUTNAM VALLEY, 2012)
Schizophrenia has been defined as a neurodevelopmental disease that causes changes in the process of thoughts, perceptions. and emotions, usually leading to a mental deterioration and affective blunting. Studies have shown ...
Injury-induced purinergic signalling molecules upregulate pluripotency gene expression and mitotic activity of progenitor cells in the zebrafish retina
(Springer, 2017-07)
Damage in fish activates retina repair that restores sight. The purinergic signalling system serves multiple homeostatic functions and has been implicated in cell cycle control of progenitor cells in the developing retina. ...
Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells? Transcription Factors
(Public Library of Science, 2015-12)
Pluripotent stem cells possess complex systems that protect them from oxidative stress and ensure genomic stability, vital for their role in development. Even though it has been reported that antioxidant activity diminishes ...
Analysis of the expression of PIWI-interacting RNAs during cardiac differentiation of human pluripotent stem cells
(Public Library of Science, 2020-05)
PIWI-interacting RNAs (piRNAs) are a class of non-coding RNAs initially thought to be restricted exclusively to germline cells. In recent years, accumulating evidence has demonstrated that piRNAs are actually expressed in ...
Regulation of cyclin E1 expression in human pluripotent stem cells and derived neural progeny
(Landes Bioscience, 2018-07)
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells (hESCs and hiPSCs) show unique cell cycle characteristics, such as a short doubling time due to an abbreviated G1 phase. Whether ...
Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199
(Public Library of Science, 2016-03)
Human embryonic stem cells (hESCs) are hypersensitive to genotoxic stress and display lower survival ability relative to their differentiated progeny. Herein, we attempted to investigate the source of this difference by ...
Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
(BioMed Central, 2017-10-18)
Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally ...
Analysis and comparison of the expression of SOX2 in blastocyst and hatched blastocyst
(Wiley-Blackwell, 2012-08-01)
Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo
(Cell Press, 2016-03)
Transcription factor (TF) binding to DNA is fundamental for gene regulation. However, it remains unknown how the dynamics of TF-DNA interactions change during cell-fate determination in vivo. Here, we use photo-activatable ...
Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells†
(Society for the Study of Reproduction, 2021-04)
The WNT signaling system plays an important but paradoxical role in the regulation of pluripotency. In the cow, IWR-1, which inhibits canonical WNT activation and has WNT-independentactions, promotes the derivation of ...