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Hemichannels Are Required for Amyloid beta-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice
(2015)
Mast cells (MCs) store an array of proinflammatory mediators in secretory granules that are rapidly released upon activation by diverse conditions including amyloid beta (A beta) peptides. In the present work, we found a ...
Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets
(Elsevier Science, 2011)
Amyloid-β (Aβ) peptides are intimately involved in the inflammatory pathology of atherosclerotic vascular disease (AVD) and Alzheimer's disease (AD). Although substantial amounts of these peptides are produced in the ...
Amyloid-β peptide remnants in AN-1792-immunized Alzheimer's disease patients: A biochemical analysis
(Amer Soc Investigative Pathology, Inc, 2006-12)
Experiments with amyloid-β (Aβ)-42-immunized transgenic mouse models of Alzheimer's disease have revealed amyloid plaque disruption and apparent cognitive function recovery. Neuropathological examination of patients ...
The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. is there a role in Alzheimer's disease?
(2011)
Amyloid β-peptide (Aβ) is the main component of the amyloid plaques associated with Alzheimer's disease (AD). In the early steps of the disease soluble Aβ oligomers are produced. According to the current "amyloid hypothesis" ...
Amyloid-Cholinesterase interactions: Implications for Alzheimer´s Disease.
(2008)
Acetylcholinesterase is an enzyme associated with senile plaques. Biochemical studies have indicated that acetylcholinesterase induces amyloid fibril formation by interaction throughout the peripherical anionic site of the ...
Insights into Alzheimer disease pathogenesis from studies in transgenic animal models
(Faculdade de Medicina / USP, 2011)
Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid ...
The role of inflammation in Alzheimer's disease
(Elsevier Science, 2005-02)
Considerable evidence gained over the past decade has supported the conclusion that neuroinflammation is associated with Alzheimer's disease (AD) pathology. Inflammatory components related to AD neuroinflammation include ...
Characterization of the beta amyloid precursor protein-like gene in the central nervous system of the crab Chasmagnathus. Expression during memory consolidation
(BioMed Central, 2010-09)
Background: Human β-amyloid, the main component in the neuritic plaques found in patients with Alzheimer's disease, is generated by cleavage of the β-amyloid precursor protein. Beyond the role in pathology, members of this ...
Self assembly of human septin 2 into amyloid filaments
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERPARIS, 2012-11)
Septins are a conserved group of GTP-binding proteins that form hetero-oligomeric complexes which assemble into filaments. These are essential for septin function, including their role in cytokinesis, cell division, ...